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Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome.
Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA. Wang M, et al. Among authors: higginbottom s. Cell. 2023 Jun 22;186(13):2839-2852.e21. doi: 10.1016/j.cell.2023.05.037. Cell. 2023. PMID: 37352836
Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs.
Ng KM, Aranda-Díaz A, Tropini C, Frankel MR, Van Treuren W, O'Loughlin CT, Merrill BD, Yu FB, Pruss KM, Oliveira RA, Higginbottom SK, Neff NF, Fischbach MA, Xavier KB, Sonnenburg JL, Huang KC. Ng KM, et al. Cell Host Microbe. 2019 Nov 13;26(5):650-665.e4. doi: 10.1016/j.chom.2019.10.011. Cell Host Microbe. 2019. PMID: 31726029 Free PMC article.
Depletion of microbiome-derived molecules in the host using Clostridium genetics.
Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. Guo CJ, et al. Among authors: higginbottom s. Science. 2019 Dec 13;366(6471):eaav1282. doi: 10.1126/science.aav1282. Science. 2019. PMID: 31831639 Free PMC article.
A metabolic pathway for bile acid dehydroxylation by the gut microbiome.
Funabashi M, Grove TL, Wang M, Varma Y, McFadden ME, Brown LC, Guo C, Higginbottom S, Almo SC, Fischbach MA. Funabashi M, et al. Among authors: higginbottom s. Nature. 2020 Jun;582(7813):566-570. doi: 10.1038/s41586-020-2396-4. Epub 2020 Jun 17. Nature. 2020. PMID: 32555455 Free PMC article.
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.
Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. Han S, et al. Among authors: higginbottom sk. Nature. 2021 Jul;595(7867):415-420. doi: 10.1038/s41586-021-03707-9. Epub 2021 Jul 14. Nature. 2021. PMID: 34262212 Free PMC article.
Design, construction, and in vivo augmentation of a complex gut microbiome.
Cheng AG, Ho PY, Aranda-Díaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA. Cheng AG, et al. Among authors: higginbottom s. Cell. 2022 Sep 15;185(19):3617-3636.e19. doi: 10.1016/j.cell.2022.08.003. Epub 2022 Sep 6. Cell. 2022. PMID: 36070752 Free PMC article.
Mapping the T cell repertoire to a complex gut bacterial community.
Nagashima K, Zhao A, Atabakhsh K, Bae M, Blum JE, Weakley A, Jain S, Meng X, Cheng AG, Wang M, Higginbottom S, Dimas A, Murugkar P, Sattely ES, Moon JJ, Balskus EP, Fischbach MA. Nagashima K, et al. Among authors: higginbottom s. Nature. 2023 Sep;621(7977):162-170. doi: 10.1038/s41586-023-06431-8. Epub 2023 Aug 16. Nature. 2023. PMID: 37587342 Free PMC article.
41 results