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Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues.
Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, Morisawa G, Yanagisawa Y, Ito E, Imai JI, Dobashi Y, Katahira K, Soeda S, Watanabe T, Fujimori K, Watanabe S, Takagi M. Tamura H, et al. Among authors: higa a. Oncol Rep. 2018 Aug;40(2):635-646. doi: 10.3892/or.2018.6501. Epub 2018 Jun 18. Oncol Rep. 2018. PMID: 29917168 Free PMC article.
Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
Yi P, Higa A, Taouji S, Bexiga MG, Marza E, Arma D, Castain C, Le Bail B, Simpson JC, Rosenbaum J, Balabaud C, Bioulac-Sage P, Blanc JF, Chevet E. Yi P, et al. Among authors: higa a. Mol Cancer Ther. 2012 Dec;11(12):2610-20. doi: 10.1158/1535-7163.MCT-12-0516. Epub 2012 Oct 5. Mol Cancer Ther. 2012. PMID: 23041544
150 results