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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z.
Rudnick DA, Huang J, Hidvegi T, Chu AS, Hale P, Munanairi A, Dietzen DJ, Cliften PF, Tycksen E, Lutkewitte AJ, Finck BN, Pak SC, Silverman GA, Perlmutter DH. Rudnick DA, et al. Among authors: hidvegi t. Gastroenterology. 2022 Jul;163(1):270-284. doi: 10.1053/j.gastro.2022.03.010. Epub 2022 Mar 15. Gastroenterology. 2022. PMID: 35301011 Free PMC article.
Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency.
Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick JAJ, Sundaramoorthi H, Pak SC, Silverman GA, Knapp B, Filipuzzi I, Alford J, Reece-Hoyes J, Nigsch F, Murphy LO, Nyfeler B, Perlmutter DH. Li J, et al. Among authors: hidvegi t. Cell Mol Gastroenterol Hepatol. 2024;17(6):1007-1024. doi: 10.1016/j.jcmgh.2024.02.006. Epub 2024 Feb 7. Cell Mol Gastroenterol Hepatol. 2024. PMID: 38336172 Free PMC article.
Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.
Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Hidvegi T, et al. J Biol Chem. 2015 Dec 11;290(50):29742-57. doi: 10.1074/jbc.M115.691253. Epub 2015 Oct 22. J Biol Chem. 2015. PMID: 26494620 Free PMC article.
77 results