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Activity-based probes for the multicatalytic proteasome.
Hewings DS, Flygare JA, Wertz IE, Bogyo M. Hewings DS, et al. FEBS J. 2017 May;284(10):1540-1554. doi: 10.1111/febs.14016. Epub 2017 Feb 7. FEBS J. 2017. PMID: 28107776 Free article. Review.
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, Flygare J, Bogyo M, Wertz IE. Hewings DS, et al. Nat Commun. 2018 Mar 21;9(1):1162. doi: 10.1038/s41467-018-03511-6. Nat Commun. 2018. PMID: 29563501 Free PMC article.
Organocatalytic removal of formaldehyde adducts from RNA and DNA bases.
Karmakar S, Harcourt EM, Hewings DS, Scherer F, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET. Karmakar S, et al. Among authors: hewings ds. Nat Chem. 2015 Sep;7(9):752-8. doi: 10.1038/nchem.2307. Epub 2015 Aug 3. Nat Chem. 2015. PMID: 26291948 Free PMC article.
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. Hewings DS, et al. J Med Chem. 2011 Oct 13;54(19):6761-70. doi: 10.1021/jm200640v. Epub 2011 Sep 6. J Med Chem. 2011. PMID: 21851057 Free PMC article.
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, Brennan PE, Conway SJ. Hewings DS, et al. J Med Chem. 2013 Apr 25;56(8):3217-27. doi: 10.1021/jm301588r. Epub 2013 Apr 5. J Med Chem. 2013. PMID: 23517011 Free PMC article.
Small molecule inhibitors of bromodomain-acetyl-lysine interactions.
Brand M, Measures AR, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ. Brand M, et al. Among authors: hewings ds. ACS Chem Biol. 2015 Jan 16;10(1):22-39. doi: 10.1021/cb500996u. ACS Chem Biol. 2015. PMID: 25549280 Review.
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ. Jennings LE, et al. Among authors: hewings ds. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15. Bioorg Med Chem. 2018. PMID: 29776834 Free article.
18 results