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DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro.
Verheijen M, Lienhard M, Schrooders Y, Clayton O, Nudischer R, Boerno S, Timmermann B, Selevsek N, Schlapbach R, Gmuender H, Gotta S, Geraedts J, Herwig R, Kleinjans J, Caiment F. Verheijen M, et al. Among authors: herwig r. Sci Rep. 2019 Mar 15;9(1):4641. doi: 10.1038/s41598-019-40660-0. Sci Rep. 2019. PMID: 30874586 Free PMC article.
Network integration and modelling of dynamic drug responses at multi-omics levels.
Selevsek N, Caiment F, Nudischer R, Gmuender H, Agarkova I, Atkinson FL, Bachmann I, Baier V, Barel G, Bauer C, Boerno S, Bosc N, Clayton O, Cordes H, Deeb S, Gotta S, Guye P, Hersey A, Hunter FMI, Kunz L, Lewalle A, Lienhard M, Merken J, Minguet J, Oliveira B, Pluess C, Sarkans U, Schrooders Y, Schuchhardt J, Smit I, Thiel C, Timmermann B, Verheijen M, Wittenberger T, Wolski W, Zerck A, Heymans S, Kuepfer L, Roth A, Schlapbach R, Niederer S, Herwig R, Kleinjans J. Selevsek N, et al. Among authors: herwig r. Commun Biol. 2020 Oct 15;3(1):573. doi: 10.1038/s42003-020-01302-8. Commun Biol. 2020. PMID: 33060801 Free PMC article.
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J. Kuepfer L, et al. Among authors: herwig r. Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. Arch Toxicol. 2018. PMID: 28852801 Free PMC article. No abstract available.
Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R. Yildirimman R, et al. Among authors: herwig r. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27. Toxicol Sci. 2011. PMID: 21873647 Free PMC article.
ToxDB: pathway-level interpretation of drug-treatment data.
Hardt C, Beber ME, Rasche A, Kamburov A, Hebels DG, Kleinjans JC, Herwig R. Hardt C, et al. Among authors: herwig r. Database (Oxford). 2016 Apr 13;2016:baw052. doi: 10.1093/database/baw052. Print 2016. Database (Oxford). 2016. PMID: 27074805 Free PMC article.
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J. Herwig R, et al. Arch Toxicol. 2016 Sep;90(9):2215-2229. doi: 10.1007/s00204-015-1617-3. Epub 2015 Nov 2. Arch Toxicol. 2016. PMID: 26525393
227 results