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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J. Georgilis A, et al. Among authors: herranz n. Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007. Cancer Cell. 2018. PMID: 29990503 Free PMC article.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. Herranz N, et al. Nat Cell Biol. 2015 Sep;17(9):1205-17. doi: 10.1038/ncb3225. Epub 2015 Aug 17. Nat Cell Biol. 2015. PMID: 26280535 Free PMC article.
Mechanisms and functions of cellular senescence.
Herranz N, Gil J. Herranz N, et al. J Clin Invest. 2018 Apr 2;128(4):1238-1246. doi: 10.1172/JCI95148. Epub 2018 Apr 2. J Clin Invest. 2018. PMID: 29608137 Free PMC article. Review.
TORn about SASP regulation.
Herranz N, Gallage S, Gil J. Herranz N, et al. Cell Cycle. 2015;14(24):3771-2. doi: 10.1080/15384101.2015.1105694. Cell Cycle. 2015. PMID: 26697828 Free PMC article. No abstract available.
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Guerrero A, et al. Among authors: herranz n. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. Nat Metab. 2019. PMID: 31799499 Free PMC article.
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.
Mellone M, Hanley CJ, Thirdborough S, Mellows T, Garcia E, Woo J, Tod J, Frampton S, Jenei V, Moutasim KA, Kabir TD, Brennan PA, Venturi G, Ford K, Herranz N, Lim KP, Clarke J, Lambert DW, Prime SS, Underwood TJ, Vijayanand P, Eliceiri KW, Woelk C, King EV, Gil J, Ottensmeier CH, Thomas GJ. Mellone M, et al. Among authors: herranz n. Aging (Albany NY). 2016 Dec 15;9(1):114-132. doi: 10.18632/aging.101127. Aging (Albany NY). 2016. PMID: 27992856 Free PMC article.
Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. Herranz N, et al. Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3243. Nat Cell Biol. 2015. PMID: 26419804 No abstract available.
Galactose-modified duocarmycin prodrugs as senolytics.
Guerrero A, Guiho R, Herranz N, Uren A, Withers DJ, Martínez-Barbera JP, Tietze LF, Gil J. Guerrero A, et al. Among authors: herranz n. Aging Cell. 2020 Apr;19(4):e13133. doi: 10.1111/acel.13133. Epub 2020 Mar 16. Aging Cell. 2020. PMID: 32175667 Free PMC article.
27 results