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X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.
Carlet M, Schmelz K, Vergalli J, Herold T, Senft D, Jurinovic V, Hoffmann T, Proba J, Weichert N, Junghanß C, Roth M, Eschenburg G, Barz M, Henze G, Eckert C, Eggert A, Zuber J, Hundsdoerfer P, Jeremias I. Carlet M, et al. Among authors: herold t. EMBO Mol Med. 2023 Jan 11;15(1):e14557. doi: 10.15252/emmm.202114557. Epub 2022 Nov 23. EMBO Mol Med. 2023. PMID: 36416169 Free PMC article.
Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.
Sandhöfer N, Metzeler KH, Rothenberg M, Herold T, Tiedt S, Groiß V, Carlet M, Walter G, Hinrichsen T, Wachter O, Grunert M, Schneider S, Subklewe M, Dufour A, Fröhling S, Klein HG, Hiddemann W, Jeremias I, Spiekermann K. Sandhöfer N, et al. Among authors: herold t. Leukemia. 2015 Apr;29(4):828-38. doi: 10.1038/leu.2014.305. Epub 2014 Oct 17. Leukemia. 2015. PMID: 25322685
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.
Bamezai S, Demir D, Pulikkottil AJ, Ciccarone F, Fischbein E, Sinha A, Borga C, Te Kronnie G, Meyer LH, Mohr F, Götze M, Caiafa P, Debatin KM, Döhner K, Döhner H, González-Menéndez I, Quintanilla-Fend L, Herold T, Jeremias I, Feuring-Buske M, Buske C, Rawat VPS. Bamezai S, et al. Among authors: herold t. Leukemia. 2021 Feb;35(2):389-403. doi: 10.1038/s41375-020-0864-3. Epub 2020 May 15. Leukemia. 2021. PMID: 32409690
Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice.
Ebinger S, Zeller C, Carlet M, Senft D, Bagnoli JW, Liu WH, Rothenberg-Thurley M, Enard W, Metzeler KH, Herold T, Spiekermann K, Vick B, Jeremias I. Ebinger S, et al. Among authors: herold t. Haematologica. 2020 Dec 1;105(12):2855-2860. doi: 10.3324/haematol.2019.226282. Haematologica. 2020. PMID: 33256387 Free PMC article. No abstract available.
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
Kempf JM, Weser S, Bartoschek MD, Metzeler KH, Vick B, Herold T, Völse K, Mattes R, Scholz M, Wange LE, Festini M, Ugur E, Roas M, Weigert O, Bultmann S, Leonhardt H, Schotta G, Hiddemann W, Jeremias I, Spiekermann K. Kempf JM, et al. Among authors: herold t. Sci Rep. 2021 Mar 12;11(1):5838. doi: 10.1038/s41598-021-84708-6. Sci Rep. 2021. PMID: 33712646 Free PMC article.
A clinically applicable gene expression-based score predicts resistance to induction treatment in acute myeloid leukemia.
Moser C, Jurinovic V, Sagebiel-Kohler S, Ksienzyk B, Batcha AMN, Dufour A, Schneider S, Rothenberg-Thurley M, Sauerland CM, Görlich D, Berdel WE, Krug U, Mansmann U, Hiddemann W, Braess J, Spiekermann K, Greif PA, Vosberg S, Metzeler KH, Kumbrink J, Herold T. Moser C, et al. Among authors: herold t. Blood Adv. 2021 Nov 23;5(22):4752-4761. doi: 10.1182/bloodadvances.2021004814. Blood Adv. 2021. PMID: 34535016 Free PMC article.
In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets.
Carlet M, Völse K, Vergalli J, Becker M, Herold T, Arner A, Senft D, Jurinovic V, Liu WH, Gao Y, Dill V, Fehse B, Baldus CD, Bastian L, Lenk L, Schewe DM, Bagnoli JW, Vick B, Schmid JP, Wilhelm A, Marschalek R, Jost PJ, Miething C, Riecken K, Schmidt-Supprian M, Binder V, Jeremias I. Carlet M, et al. Among authors: herold t. Nat Commun. 2021 Sep 27;12(1):5655. doi: 10.1038/s41467-021-25963-z. Nat Commun. 2021. PMID: 34580292 Free PMC article.
285 results