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5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM. Meneyrol J, et al. Among authors: herbert jm. J Med Chem. 2013 Dec 12;56(23):9441-56. doi: 10.1021/jm4005835. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24175584
N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
Boldron C, Besse A, Bordes MF, Tissandié S, Yvon X, Gau B, Badorc A, Rousseaux T, Barré G, Meneyrol J, Zech G, Nazare M, Fossey V, Pflieger AM, Bonnet-Lignon S, Millet L, Briot C, Dol F, Hérault JP, Savi P, Lassalle G, Delesque N, Herbert JM, Bono F. Boldron C, et al. Among authors: herbert jm. J Med Chem. 2014 Sep 11;57(17):7293-316. doi: 10.1021/jm500588w. Epub 2014 Aug 25. J Med Chem. 2014. PMID: 25075638
SSR182289A, a selective and potent orally active thrombin inhibitor.
Altenburger JM, Lassalle GY, Matrougui M, Galtier D, Jetha JC, Bocskei Z, Berry CN, Lunven C, Lorrain J, Herault JP, Schaeffer P, O'Connor SE, Herbert JM. Altenburger JM, et al. Among authors: herbert jm. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. doi: 10.1016/j.bmc.2004.01.016. Bioorg Med Chem. 2004. PMID: 15028263
Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: this mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs.
Fons P, Gueguen-Dorbes G, Herault JP, Geronimi F, Tuyaret J, Frédérique D, Schaeffer P, Volle-Challier C, Herbert JM, Bono F. Fons P, et al. Among authors: herbert jm. J Cell Physiol. 2015 Jan;230(1):43-51. doi: 10.1002/jcp.24656. J Cell Physiol. 2015. PMID: 24760775
Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel.
Lorrain J, Lechaire I, Gauffeny C, Masson R, Roome N, Herault JP, O'Connor SE, Schaeffer P, Herbert JM. Lorrain J, et al. Among authors: herbert jm. J Pharmacol Exp Ther. 2004 Apr;309(1):235-40. doi: 10.1124/jpet.103.059873. Epub 2004 Jan 12. J Pharmacol Exp Ther. 2004. PMID: 14718579
Targeted identification of sialoglycoproteins in hypoxic endothelial cells and validation in zebrafish reveal roles for proteins in angiogenesis.
Delcourt N, Quevedo C, Nonne C, Fons P, O'Brien D, Loyaux D, Diez M, Autelitano F, Guillemot JC, Ferrara P, Muriana A, Callol C, Hérault JP, Herbert JM, Favre G, Bono F. Delcourt N, et al. Among authors: herbert jm. J Biol Chem. 2015 Feb 6;290(6):3405-17. doi: 10.1074/jbc.M114.618611. Epub 2014 Nov 10. J Biol Chem. 2015. PMID: 25384978 Free PMC article.
439 results