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Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Stevens AM, Xiang M, Heppler LN, Tošić I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA. Stevens AM, et al. Among authors: heppler ln. Blood Adv. 2019 Dec 23;3(24):4215-4227. doi: 10.1182/bloodadvances.2019000499. Blood Adv. 2019. PMID: 31856268 Free PMC article.
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.
Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA. Xiang M, et al. Among authors: heppler ln. Blood. 2016 Oct 6;128(14):1845-1853. doi: 10.1182/blood-2015-07-660506. Epub 2016 Aug 16. Blood. 2016. PMID: 27531676 Free PMC article.
Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
Brown JR, Walker SR, Heppler LN, Tyekucheva S, Nelson EA, Klitgaard J, Nicolais M, Kroll Y, Xiang M, Yeh JE, Chaudhury M, Giaccone ZT, Fernandes SM, Jacobsen ED, Fisher DC, Freedman AS, Davids MS, Supko JG, Wu C, Frank DA. Brown JR, et al. Among authors: heppler ln. Am J Hematol. 2021 Apr 1;96(4):E95-E98. doi: 10.1002/ajh.26084. Epub 2021 Jan 11. Am J Hematol. 2021. PMID: 33373063 Free PMC article. Clinical Trial. No abstract available.
Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles.
Tošić I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Moore EAG, Pal S, Richardson DS, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA. Tošić I, et al. Among authors: heppler ln. Mol Cancer Ther. 2021 Apr;20(4):726-738. doi: 10.1158/1535-7163.MCT-20-0505. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536189 Free PMC article.