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The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.
Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FG, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG. Brecklinghaus T, et al. Among authors: hengstler jg. Chem Biol Interact. 2022 Jan 5;351:109728. doi: 10.1016/j.cbi.2021.109728. Epub 2021 Oct 27. Chem Biol Interact. 2022. PMID: 34717914 Free article.
Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.
Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R. Gu X, et al. Among authors: hengstler jg. Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13. Arch Toxicol. 2018. PMID: 30317417
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes.
Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Zhang M, Gardner I, Marchan R, Ghallab A, Demirci Turgunbayer Ö, Rahnenführer J, Hengstler JG. Brecklinghaus T, et al. Among authors: hengstler jg. Toxicol In Vitro. 2022 Jun;81:105344. doi: 10.1016/j.tiv.2022.105344. Epub 2022 Mar 6. Toxicol In Vitro. 2022. PMID: 35263627
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay.
Brecklinghaus T, Albrecht W, Duda J, Kappenberg F, Gründler L, Edlund K, Marchan R, Ghallab A, Cadenas C, Rieck A, Vartak N, Tolosa L, Castell JV, Gardner I, Halilbasic E, Trauner M, Ullrich A, Zeigerer A, Demirci Turgunbayer Ö, Damm G, Seehofer D, Rahnenführer J, Hengstler JG. Brecklinghaus T, et al. Among authors: hengstler jg. Toxicol Lett. 2022 Sep 1;368:33-46. doi: 10.1016/j.toxlet.2022.08.006. Epub 2022 Aug 10. Toxicol Lett. 2022. PMID: 35963427
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.
Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG. Grinberg M, et al. Among authors: hengstler jg. Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3. Arch Toxicol. 2018. PMID: 30511339
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG. Albrecht W, et al. Among authors: hengstler jg. Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27. Arch Toxicol. 2019. PMID: 31250071
Handling deviating control values in concentration-response curves.
Kappenberg F, Brecklinghaus T, Albrecht W, Blum J, van der Wurp C, Leist M, Hengstler JG, Rahnenführer J. Kappenberg F, et al. Among authors: hengstler jg. Arch Toxicol. 2020 Nov;94(11):3787-3798. doi: 10.1007/s00204-020-02913-0. Epub 2020 Sep 23. Arch Toxicol. 2020. PMID: 32965549 Free PMC article.
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG. Ghallab A, et al. Among authors: hengstler jg. J Hepatol. 2022 Jul;77(1):71-83. doi: 10.1016/j.jhep.2022.01.020. Epub 2022 Feb 5. J Hepatol. 2022. PMID: 35131407 Free PMC article.
Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test.
Cherianidou A, Seidel F, Kappenberg F, Dreser N, Blum J, Waldmann T, Blüthgen N, Meisig J, Madjar K, Henry M, Rotshteyn T, Marchan R, Edlund K, Leist M, Rahnenführer J, Sachinidis A, Hengstler JG. Cherianidou A, et al. Among authors: hengstler jg. Chem Res Toxicol. 2022 May 16;35(5):760-773. doi: 10.1021/acs.chemrestox.1c00392. Epub 2022 Apr 13. Chem Res Toxicol. 2022. PMID: 35416653 Free PMC article.
550 results