NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.
Heneka MT, et al.
Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.
Nature. 2013.
PMID: 23254930
Free PMC article.