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Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient.
Van Nuffel AM, Benteyn D, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A. Van Nuffel AM, et al. Among authors: heirman c. Cancer Immunol Immunother. 2012 Jul;61(7):1033-43. doi: 10.1007/s00262-011-1176-2. Epub 2011 Dec 10. Cancer Immunol Immunother. 2012. PMID: 22159452 Free PMC article. Clinical Trial.
Preclinical evaluation of TriMix and antigen mRNA-based antitumor therapy.
Van Lint S, Goyvaerts C, Maenhout S, Goethals L, Disy A, Benteyn D, Pen J, Bonehill A, Heirman C, Breckpot K, Thielemans K. Van Lint S, et al. Among authors: heirman c. Cancer Res. 2012 Apr 1;72(7):1661-71. doi: 10.1158/0008-5472.CAN-11-2957. Epub 2012 Feb 15. Cancer Res. 2012. PMID: 22337996
Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.
Pen JJ, De Keersmaecker B, Maenhout SK, Van Nuffel AM, Heirman C, Corthals J, Escors D, Bonehill A, Thielemans K, Breckpot K, Aerts JL. Pen JJ, et al. Among authors: heirman c. J Immunol. 2013 Aug 15;191(4):1976-83. doi: 10.4049/jimmunol.1201008. Epub 2013 Jul 10. J Immunol. 2013. PMID: 23842750
Optimized dendritic cell-based immunotherapy for melanoma: the TriMix-formula.
Van Lint S, Wilgenhof S, Heirman C, Corthals J, Breckpot K, Bonehill A, Neyns B, Thielemans K. Van Lint S, et al. Among authors: heirman c. Cancer Immunol Immunother. 2014 Sep;63(9):959-67. doi: 10.1007/s00262-014-1558-3. Epub 2014 May 31. Cancer Immunol Immunother. 2014. PMID: 24878889 Free PMC article. Review.
mRNA-based dendritic cell vaccines.
Benteyn D, Heirman C, Bonehill A, Thielemans K, Breckpot K. Benteyn D, et al. Among authors: heirman c. Expert Rev Vaccines. 2015 Feb;14(2):161-76. doi: 10.1586/14760584.2014.957684. Epub 2014 Sep 8. Expert Rev Vaccines. 2015. PMID: 25196947 Review.
107 results