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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.
Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3.
Biophys J. 2019.
PMID: 31130234
Free PMC article.
Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.
Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D.
Kamp F, et al. Among authors: heinel h.
ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713. doi: 10.1021/acschemneuro.8b00068. Epub 2018 May 11.
ACS Chem Neurosci. 2018.
PMID: 29717863
Free PMC article.
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