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Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology.
Schrammen PL, Ghaffari Laleh N, Echle A, Truhn D, Schulz V, Brinker TJ, Brenner H, Chang-Claude J, Alwers E, Brobeil A, Kloor M, Heij LR, Jäger D, Trautwein C, Grabsch HI, Quirke P, West NP, Hoffmeister M, Kather JN. Schrammen PL, et al. Among authors: heij lr. J Pathol. 2022 Jan;256(1):50-60. doi: 10.1002/path.5800. Epub 2021 Oct 22. J Pathol. 2022. PMID: 34561876 Free article.
Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning.
Echle A, Grabsch HI, Quirke P, van den Brandt PA, West NP, Hutchins GGA, Heij LR, Tan X, Richman SD, Krause J, Alwers E, Jenniskens J, Offermans K, Gray R, Brenner H, Chang-Claude J, Trautwein C, Pearson AT, Boor P, Luedde T, Gaisa NT, Hoffmeister M, Kather JN. Echle A, et al. Among authors: heij lr. Gastroenterology. 2020 Oct;159(4):1406-1416.e11. doi: 10.1053/j.gastro.2020.06.021. Epub 2020 Jun 17. Gastroenterology. 2020. PMID: 32562722 Free PMC article.
Nerve fibers in the tumor microenvironment in neurotropic cancer-pancreatic cancer and cholangiocarcinoma.
Tan X, Sivakumar S, Bednarsch J, Wiltberger G, Kather JN, Niehues J, de Vos-Geelen J, Valkenburg-van Iersel L, Kintsler S, Roeth A, Hao G, Lang S, Coolsen ME, den Dulk M, Aberle MR, Koolen J, Gaisa NT, Olde Damink SWM, Neumann UP, Heij LR. Tan X, et al. Among authors: heij lr. Oncogene. 2021 Feb;40(5):899-908. doi: 10.1038/s41388-020-01578-4. Epub 2020 Dec 7. Oncogene. 2021. PMID: 33288884 Free PMC article. Review.
Pan-cancer image-based detection of clinically actionable genetic alterations.
Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Ortiz-Brüchle NN, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, Jäger D, Trautwein C, Pearson AT, Luedde T. Kather JN, et al. Among authors: heij lr. Nat Cancer. 2020 Aug;1(8):789-799. doi: 10.1038/s43018-020-0087-6. Epub 2020 Jul 27. Nat Cancer. 2020. PMID: 33763651 Free PMC article.
The Presence of Small Nerve Fibers in the Tumor Microenvironment as Predictive Biomarker of Oncological Outcome Following Partial Hepatectomy for Intrahepatic Cholangiocarcinoma.
Bednarsch J, Tan X, Czigany Z, Liu D, Lang SA, Sivakumar S, Kather JN, Appinger S, Rosin M, Boroojerdi S, Dahl E, Gaisa NT, den Dulk M, Coolsen M, Ulmer TF, Neumann UP, Heij LR. Bednarsch J, et al. Among authors: heij lr. Cancers (Basel). 2021 Jul 21;13(15):3661. doi: 10.3390/cancers13153661. Cancers (Basel). 2021. PMID: 34359564 Free PMC article.
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