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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
Prokopenko D, Lee S, Hecker J, Mullin K, Morgan S, Katsumata Y; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Weiner MW, Fardo DW, Laird N, Bertram L, Hide W, Lange C, Tanzi RE. Prokopenko D, et al. Among authors: hecker j. Mol Psychiatry. 2022 Apr;27(4):1963-1969. doi: 10.1038/s41380-022-01475-0. Epub 2022 Mar 4. Mol Psychiatry. 2022. PMID: 35246634 Free PMC article.
Using Network Methodology to Infer Population Substructure.
Prokopenko D, Hecker J, Silverman E, Nöthen MM, Schmid M, Lange C, Loehlein Fier H. Prokopenko D, et al. Among authors: hecker j. PLoS One. 2015 Jun 22;10(6):e0130708. doi: 10.1371/journal.pone.0130708. eCollection 2015. PLoS One. 2015. PMID: 26098940 Free PMC article.
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.
Chang H, Hoshina N, Zhang C, Ma Y, Cao H, Wang Y, Wu DD, Bergen SE, Landén M, Hultman CM, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nöthen MM; Swedish Bipolar Study Group; MooDS Bipolar Consortium; Walter H, Erk S, Heinz A, Amin N, van Duijn CM, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M, Li M. Chang H, et al. Among authors: hecker j. Mol Psychiatry. 2018 Feb;23(2):400-412. doi: 10.1038/mp.2016.231. Epub 2017 Jan 10. Mol Psychiatry. 2018. PMID: 28070120 Free PMC article.
Reporting Correct p Values in VEGAS Analyses.
Hecker J, Maaser A, Prokopenko D, Fier HL, Lange C. Hecker J, et al. Twin Res Hum Genet. 2017 Jun;20(3):257-259. doi: 10.1017/thg.2017.16. Epub 2017 Mar 27. Twin Res Hum Genet. 2017. PMID: 28345502 Free PMC article.
Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.
Xiao X, Wang L, Wang C, Yuan TF, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nöthen MM, Chang H, Luo XJ, Fang Y, Yao YG, Zhang C, Rietschel M, Li M; Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium. Xiao X, et al. Among authors: hecker j. Transl Psychiatry. 2017 Dec 11;7(12):1273. doi: 10.1038/s41398-017-0019-0. Transl Psychiatry. 2017. PMID: 29225345 Free PMC article.
251 results