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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S. Causevic M, et al. Among authors: hecimovic s. PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018. PLoS One. 2018. PMID: 29979789 Free PMC article.
Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway.
Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S. Malnar M, et al. Among authors: hecimovic s. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):682-91. doi: 10.1016/j.bbadis.2010.05.006. Epub 2010 May 20. Biochim Biophys Acta. 2010. PMID: 20493254 Free PMC article.
Amyloid-β metabolism in Niemann-Pick C disease models and patients.
Mattsson N, Olsson M, Gustavsson MK, Kosicek M, Malnar M, Månsson JE, Blomqvist M, Gobom J, Andreasson U, Brinkmalm G, Vite C, Hecimovic S, Hastings C, Blennow K, Zetterberg H, Portelius E. Mattsson N, et al. Among authors: hecimovic s. Metab Brain Dis. 2012 Dec;27(4):573-85. doi: 10.1007/s11011-012-9332-8. Epub 2012 Sep 1. Metab Brain Dis. 2012. PMID: 22935999
44 results