Hecht S - Search Results

1

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D. Clarke PA, et al. Among authors: hecht s. Elife. 2016 Dec 9;5:e20722. doi: 10.7554/eLife.20722. Elife. 2016. PMID: 27935476 Free PMC article.

2

A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide.

Lüpfert C, Dyroff M, von Richter O, Gallemann D, El Bawab S, Dolgos H, Jung D, Hecht S, Johne A. Lüpfert C, et al. Among authors: hecht s. CPT Pharmacometrics Syst Pharmacol. 2018 Dec;7(12):829-837. doi: 10.1002/psp4.12360. Epub 2018 Oct 31. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30311747 Free PMC article.

3

Changes in blood pressure after administration of hydroxocobalamin: relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers.

Uhl W, Nolting A, Gallemann D, Hecht S, Kovar A. Uhl W, et al. Among authors: hecht s. Clin Toxicol (Phila). 2008 Jul;46(6):551-9; discussion 576-7. doi: 10.1080/15563650701829763. Clin Toxicol (Phila). 2008. PMID: 18584369 Clinical Trial.

4

Generation and Characterization of Iduronidase-Cleavable ADCs.

Jäger S, Könning D, Rasche N, Hart F, Sensbach J, Krug C, Raab-Westphal S, Richter K, Unverzagt C, Hecht S, Anderl J, Schröter C. Jäger S, et al. Among authors: hecht s. Bioconjug Chem. 2023 Dec 20;34(12):2221-2233. doi: 10.1021/acs.bioconjchem.3c00363. Epub 2023 Dec 6. Bioconjug Chem. 2023. PMID: 38054705

5

EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing.

Jäger S, Dickgiesser S, Tonillo J, Hecht S, Kolmar H, Schröter C. Jäger S, et al. Among authors: hecht s. Biol Chem. 2021 Sep 20;403(5-6):525-534. doi: 10.1515/hsz-2021-0321. Print 2022 Apr 26. Biol Chem. 2021. PMID: 34535048 Free article.

6

Isolation of Anti-Hapten Antibodies by Fluorescence-Activated Cell Sorting of Yeast-Displayed B-Cell Receptor Gene Repertoires.

Jäger S, Krah S, Könning D, Rosskopf J, Dickgiesser S, Rasche N, Kolmar H, Hecht S, Schröter C. Jäger S, et al. Among authors: hecht s. Methods Mol Biol. 2020;2070:267-287. doi: 10.1007/978-1-4939-9853-1_15. Methods Mol Biol. 2020. PMID: 31625101

7

Site-Specific Conjugation of Native Antibodies Using Engineered Microbial Transglutaminases.

Dickgiesser S, Rieker M, Mueller-Pompalla D, Schröter C, Tonillo J, Warszawski S, Raab-Westphal S, Kühn S, Knehans T, Könning D, Dotterweich J, Betz UAK, Anderl J, Hecht S, Rasche N. Dickgiesser S, et al. Among authors: hecht s. Bioconjug Chem. 2020 Apr 15;31(4):1070-1076. doi: 10.1021/acs.bioconjchem.0c00061. Epub 2020 Mar 12. Bioconjug Chem. 2020. PMID: 32134638

8

Generation and Biological Evaluation of Fc Antigen Binding Fragment-Drug Conjugates as a Novel Antibody-Based Format for Targeted Drug Delivery.

Jäger S, Wagner TR, Rasche N, Kolmar H, Hecht S, Schröter C. Jäger S, et al. Among authors: hecht s. Bioconjug Chem. 2021 Aug 18;32(8):1699-1710. doi: 10.1021/acs.bioconjchem.1c00240. Epub 2021 Jun 29. Bioconjug Chem. 2021. PMID: 34185508

9

Effect of Conjugation Site and Technique on the Stability and Pharmacokinetics of Antibody-Drug Conjugates.

Kaempffe A, Dickgiesser S, Rasche N, Paoletti A, Bertotti E, De Salve I, Sirtori FR, Kellner R, Könning D, Hecht S, Anderl J, Kolmar H, Schröter C. Kaempffe A, et al. Among authors: hecht s. J Pharm Sci. 2021 Dec;110(12):3776-3785. doi: 10.1016/j.xphs.2021.08.002. Epub 2021 Aug 4. J Pharm Sci. 2021. PMID: 34363839

10

Solar Azo-Switches for Effective E→Z Photoisomerization by Sunlight.

Zhang ZY, Dong D, Bösking T, Dang T, Liu C, Sun W, Xie M, Hecht S, Li T. Zhang ZY, et al. Among authors: hecht s. Angew Chem Int Ed Engl. 2024 May 9:e202404528. doi: 10.1002/anie.202404528. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 38722260

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