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Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Moyer BJ, Rojas IY, Kerley-Hamilton JS, Hazlett HF, Nemani KV, Trask HW, West RJ, Lupien LE, Collins AJ, Ringelberg CS, Gimi B, Kinlaw WB 3rd, Tomlinson CR. Moyer BJ, et al. Among authors: hazlett hf. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. doi: 10.1016/j.taap.2016.03.011. Epub 2016 Mar 25. Toxicol Appl Pharmacol. 2016. PMID: 27020609 Free PMC article.
Exposure to extracellular vesicles from Pseudomonas aeruginosa result in loss of DNA methylation at enhancer and DNase hypersensitive site regions in lung macrophages.
Kyung Lee M, Armstrong DA, Hazlett HF, Dessaint JA, Mellinger DL, Aridgides DS, Christensen BC, Ashare A. Kyung Lee M, et al. Among authors: hazlett hf. Epigenetics. 2021 Nov;16(11):1187-1200. doi: 10.1080/15592294.2020.1853318. Epub 2020 Dec 31. Epigenetics. 2021. PMID: 33380271 Free PMC article.
Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps.
Skopelja-Gardner S, Theprungsirikul J, Lewis KA, Hammond JH, Carlson KM, Hazlett HF, Nymon A, Nguyen D, Berwin BL, Hogan DA, Rigby WFC. Skopelja-Gardner S, et al. Among authors: hazlett hf. Front Immunol. 2019 Jul 18;10:1670. doi: 10.3389/fimmu.2019.01670. eCollection 2019. Front Immunol. 2019. PMID: 31379861 Free PMC article.