Haynes RK - Search Results

1

Absorptive and Secretory Transport of Selected Artemisinin Derivatives Across Caco-2 Cell Monolayers.

Heyns J, Willers C, Haynes RK, Wong HN, Hamman J, Gouws C. Heyns J, et al. Among authors: haynes rk. Curr Drug Deliv. 2018;15(8):1183-1192. doi: 10.2174/1567201815666180518125113. Curr Drug Deliv. 2018. PMID: 29779481

2

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D. Haynes RK, et al. Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708. Infect Disord Drug Targets. 2013. PMID: 24304352 Review.

3

The Case for Development of 11-Aza-artemisinins for Malaria.

Harmse R, Wong HN, Smit F, Haynes RK, N'Da DD. Harmse R, et al. Among authors: haynes rk. Curr Med Chem. 2015;22(31):3607-30. doi: 10.2174/0929867322666150729115752. Curr Med Chem. 2015. PMID: 26219389 Review.

4

Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model.

Müller J, Aguado-Martínez A, Manser V, Wong HN, Haynes RK, Hemphill A. Müller J, et al. Among authors: haynes rk. Vet Res. 2016 Feb 17;47:32. doi: 10.1186/s13567-016-0317-1. Vet Res. 2016. PMID: 26883424 Free PMC article.

5

Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins.

Wu Y, Wu RW, Cheu KW, Williams ID, Krishna S, Slavic K, Gravett AM, Liu WM, Wong HN, Haynes RK. Wu Y, et al. Among authors: haynes rk. ChemMedChem. 2016 Jul 5;11(13):1469-79. doi: 10.1002/cmdc.201600011. Epub 2016 Jun 7. ChemMedChem. 2016. PMID: 27273875

6

Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.

Gold D, Alian M, Domb A, Karawani Y, Jbarien M, Chollet J, Haynes RK, Wong HN, Buchholz V, Greiner A, Golenser J. Gold D, et al. Among authors: haynes rk. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):241-247. doi: 10.1016/j.ijpddr.2017.05.002. Epub 2017 May 4. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28511056 Free PMC article.

7

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis.

Morake M, Coertzen D, Ngwane A, Wentzel JF, Wong HN, Smit FJ, Birkholtz LM, Pietersen RD, Baker B, Wiid I, N'Da DD, Haynes RK. Morake M, et al. Among authors: haynes rk. ChemMedChem. 2018 Jan 8;13(1):67-77. doi: 10.1002/cmdc.201700579. Epub 2017 Dec 15. ChemMedChem. 2018. PMID: 29193799

8

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities.

Harmse R, Wong HN, Smit FJ, Müller J, Hemphill A, N'Da DD, Haynes RK. Harmse R, et al. Among authors: haynes rk. ChemMedChem. 2017 Dec 19;12(24):2094-2098. doi: 10.1002/cmdc.201700600. Epub 2017 Dec 6. ChemMedChem. 2017. PMID: 29210523

9

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

Harmse R, Coertzen D, Wong HN, Smit FJ, van der Watt ME, Reader J, Nondaba SH, Birkholtz LM, Haynes RK, N'Da DD. Harmse R, et al. Among authors: haynes rk. ChemMedChem. 2017 Dec 19;12(24):2086-2093. doi: 10.1002/cmdc.201700599. Epub 2017 Dec 8. ChemMedChem. 2017. PMID: 29219249

10

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives.

de Lange C, Coertzen D, Smit FJ, Wentzel JF, Wong HN, Birkholtz LM, Haynes RK, N'Da DD. de Lange C, et al. Among authors: haynes rk. Bioorg Med Chem Lett. 2018 Feb 1;28(3):289-292. doi: 10.1016/j.bmcl.2017.12.057. Epub 2017 Dec 26. Bioorg Med Chem Lett. 2018. PMID: 29317166

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