Hayakawa H - Search Results

1

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.

Nakamori M, Panigrahi GB, Lanni S, Gall-Duncan T, Hayakawa H, Tanaka H, Luo J, Otabe T, Li J, Sakata A, Caron MC, Joshi N, Prasolava T, Chiang K, Masson JY, Wold MS, Wang X, Lee MYWT, Huddleston J, Munson KM, Davidson S, Layeghifard M, Edward LM, Gallon R, Santibanez-Koref M, Murata A, Takahashi MP, Eichler EE, Shlien A, Nakatani K, Mochizuki H, Pearson CE. Nakamori M, et al. Among authors: hayakawa h. Nat Genet. 2020 Feb;52(2):146-159. doi: 10.1038/s41588-019-0575-8. Epub 2020 Feb 14. Nat Genet. 2020. PMID: 32060489 Free PMC article.

2

Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.

Beck G, Shinzawa K, Hayakawa H, Baba K, Yasuda T, Sumi-Akamaru H, Tsujimoto Y, Mochizuki H. Beck G, et al. Among authors: hayakawa h. PLoS One. 2015 Oct 27;10(10):e0141629. doi: 10.1371/journal.pone.0141629. eCollection 2015. PLoS One. 2015. PMID: 26506412 Free PMC article.

3

Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A2β Knockout Mice.

Beck G, Shinzawa K, Hayakawa H, Baba K, Sumi-Akamaru H, Tsujimoto Y, Mochizuki H. Beck G, et al. Among authors: hayakawa h. PLoS One. 2016 Apr 14;11(4):e0153789. doi: 10.1371/journal.pone.0153789. eCollection 2016. PLoS One. 2016. PMID: 27078024 Free PMC article.

4

In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease.

Uenaka T, Satake W, Cha PC, Hayakawa H, Baba K, Jiang S, Kobayashi K, Kanagawa M, Okada Y, Mochizuki H, Toda T. Uenaka T, et al. Among authors: hayakawa h. Hum Mol Genet. 2018 Nov 15;27(22):3974-3985. doi: 10.1093/hmg/ddy279. Hum Mol Genet. 2018. PMID: 30137437 Free PMC article.

5

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.

Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H. Uehara T, et al. Among authors: hayakawa h. Sci Rep. 2019 May 21;9(1):7567. doi: 10.1038/s41598-019-43772-9. Sci Rep. 2019. PMID: 31110191 Free PMC article.

6

E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.

Sakai R, Suzuki M, Ueyama M, Takeuchi T, Minakawa EN, Hayakawa H, Baba K, Mochizuki H, Nagai Y. Sakai R, et al. Among authors: hayakawa h. PLoS One. 2019 Jun 26;14(6):e0218261. doi: 10.1371/journal.pone.0218261. eCollection 2019. PLoS One. 2019. PMID: 31242217 Free PMC article.

7

Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Furuya T, Hayakawa H, Yamada M, Yoshimi K, Hisahara S, Miura M, Mizuno Y, Mochizuki H. Furuya T, et al. Among authors: hayakawa h. J Neurosci. 2004 Feb 25;24(8):1865-72. doi: 10.1523/JNEUROSCI.3309-03.2004. J Neurosci. 2004. PMID: 14985426 Free PMC article.

8

Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone.

Tani M, Hayakawa H, Yasuda T, Nihira T, Hattori N, Mizuno Y, Mochizuki H. Tani M, et al. Among authors: hayakawa h. J Neurochem. 2010 Nov;115(4):854-63. doi: 10.1111/j.1471-4159.2010.06727.x. J Neurochem. 2010. PMID: 20374434 Free article.

9

Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.

Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H. Yasuda T, et al. Among authors: hayakawa h. J Neuropathol Exp Neurol. 2011 Aug;70(8):686-97. doi: 10.1097/NEN.0b013e3182269ecd. J Neuropathol Exp Neurol. 2011. PMID: 21760537

10

Accumulation of α-synuclein triggered by presynaptic dysfunction.

Nakata Y, Yasuda T, Fukaya M, Yamamori S, Itakura M, Nihira T, Hayakawa H, Kawanami A, Kataoka M, Nagai M, Sakagami H, Takahashi M, Mizuno Y, Mochizuki H. Nakata Y, et al. Among authors: hayakawa h. J Neurosci. 2012 Nov 28;32(48):17186-96. doi: 10.1523/JNEUROSCI.2220-12.2012. J Neurosci. 2012. PMID: 23197711 Free PMC article.

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