Hay E - Search Results

1

Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

Symons RA, Colella F, Collins FL, Rafipay AJ, Kania K, McClure JJ, White N, Cunningham I, Ashraf S, Hay E, Mackenzie KS, Howard KA, Riemen AHK, Manzo A, Clark SM, Roelofs AJ, De Bari C. Symons RA, et al. Among authors: hay e. Ann Rheum Dis. 2022 Feb;81(2):214-224. doi: 10.1136/annrheumdis-2021-220875. Epub 2021 Nov 29. Ann Rheum Dis. 2022. PMID: 34844926 Free PMC article.

2

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome.

Hay EA, Khalaf AR, Marini P, Brown A, Heath K, Sheppard D, MacKenzie A. Hay EA, et al. Neuropeptides. 2017 Aug;64:101-107. doi: 10.1016/j.npep.2016.11.003. Epub 2016 Nov 4. Neuropeptides. 2017. PMID: 27866656 Free PMC article.

3

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation.

Hay EA, Knowles C, Kolb A, MacKenzie A. Hay EA, et al. Neuropeptides. 2017 Aug;64:19-25. doi: 10.1016/j.npep.2016.11.010. Epub 2016 Dec 3. Neuropeptides. 2017. PMID: 28038787 Free PMC article. Review.

4

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake.

McEwan AR, Davidson C, Hay E, Turnbull Y, Erickson JC, Marini P, Wilson D, McIntosh AM, Adams MJ, Murgatroyd C, Barrett P, Delibegovic M, Clarke TK, MacKenzie A. McEwan AR, et al. Among authors: hay e. Mol Psychiatry. 2021 Jun;26(6):2263-2276. doi: 10.1038/s41380-020-0707-7. Epub 2020 Mar 13. Mol Psychiatry. 2021. PMID: 32203157

5

The noncoding human genome and the future of personalised medicine.

Cowie P, Hay EA, MacKenzie A. Cowie P, et al. Expert Rev Mol Med. 2015 Jan 30;17:e4. doi: 10.1017/erm.2014.23. Expert Rev Mol Med. 2015. PMID: 25634368 Review.

6

Determining Epigenetic Targets: A Beginner's Guide to Identifying Genome Functionality Through Database Analysis.

Hay EA, Cowie P, MacKenzie A. Hay EA, et al. Methods Mol Biol. 2017;1589:29-45. doi: 10.1007/7651_2015_263. Methods Mol Biol. 2017. PMID: 26025621

7

Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour.

Hay EA, McEwan A, Wilson D, Barrett P, D'Agostino G, Pertwee RG, MacKenzie A. Hay EA, et al. Psychoneuroendocrinology. 2019 Nov;109:104407. doi: 10.1016/j.psyneuen.2019.104407. Epub 2019 Aug 13. Psychoneuroendocrinology. 2019. PMID: 31445429 Free PMC article.

8

Disease-associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue-specific activity of the cannabinoid-1 receptor gene promoter; implications for cannabinoid pharmacogenetics.

Hay EA, Cowie P, McEwan AR, Ross R, Pertwee RG, MacKenzie A. Hay EA, et al. Hum Mutat. 2020 Jan;41(1):291-298. doi: 10.1002/humu.23931. Epub 2019 Nov 4. Hum Mutat. 2020. PMID: 31608546 Free PMC article.

9

Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities.

MacKenzie A, Hay EA, McEwan AR. MacKenzie A, et al. Addict Neurosci. 2022 Jun;2:None. doi: 10.1016/j.addicn.2022.100014. Addict Neurosci. 2022. PMID: 35712020 Free PMC article. Review.

10

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4.

Sergi D, Morris AC, Kahn DE, McLean FH, Hay EA, Kubitz P, MacKenzie A, Martinoli MG, Drew JE, Williams LM. Sergi D, et al. Among authors: hay ea. Nutr Neurosci. 2020 Apr;23(4):321-334. doi: 10.1080/1028415X.2018.1501533. Epub 2018 Jul 21. Nutr Neurosci. 2020. PMID: 30032721

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