Hawes B - Search Results

1

Polypharmacy through Phage Display: Selection of Glucagon and GLP-1 Receptor Co-agonists from a Phage-Displayed Peptide Library.

Demartis A, Lahm A, Tomei L, Beghetto E, Di Biasio V, Orvieto F, Frattolillo F, Carrington PE, Mumick S, Hawes B, Bianchi E, Palani A, Pessi A. Demartis A, et al. Among authors: hawes b. Sci Rep. 2018 Jan 12;8(1):585. doi: 10.1038/s41598-017-18494-5. Sci Rep. 2018. PMID: 29330364 Free PMC article.

2

Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.

Palani A, Nawrocki AR, Orvieto F, Bianchi E, Mandić E, Pessi A, Huang C, Deng Q, Toussaint N, Walsh E, Reddy V, Ashley E, He H, Mumick S, Hawes B, Marsh D, Erion M, Nargund R, Carrington PE. Palani A, et al. Among authors: hawes b. ACS Med Chem Lett. 2022 Jul 21;13(8):1248-1254. doi: 10.1021/acsmedchemlett.2c00217. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978682 Free PMC article.

3

Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, O'Neill K, Hawes B. Palani A, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5234-6. doi: 10.1016/j.bmcl.2005.08.043. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202583

4

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. Among authors: hawes b. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

5

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

6

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: hawes be. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926

7

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Xu R, Li S, Paruchova J, McBriar MD, Guzik H, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B, Weston DJ. Xu R, et al. Among authors: hawes be. Bioorg Med Chem. 2006 May 15;14(10):3285-99. doi: 10.1016/j.bmc.2005.12.046. Epub 2006 Jan 26. Bioorg Med Chem. 2006. PMID: 16442800

8

Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists.

Dai X, Stamford A, Liu H, Neustadt B, Hao J, Kowalski T, Hawes B, Xu X, Baker H, O'Neill K, Woods M, Tang H, Greenlee W. Dai X, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5291-4. doi: 10.1016/j.bmcl.2015.09.047. Epub 2015 Sep 21. Bioorg Med Chem Lett. 2015. PMID: 26433449

9

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.

Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T. Xia Y, et al. Among authors: hawes b. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. doi: 10.1016/j.bmcl.2011.04.035. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536438

10

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis.

Su J, McKittrick BA, Tang H, Czarniecki M, Greenlee WJ, Hawes BE, O'Neill K. Su J, et al. Bioorg Med Chem. 2005 Mar 1;13(5):1829-36. doi: 10.1016/j.bmc.2004.11.046. Bioorg Med Chem. 2005. PMID: 15698800

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