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3D-Informed Targeting of the Trop-2 Signal-Activation Site Drives Selective Cancer Vulnerability.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Ceci M, Boujnah K, Pantalone L, Sacchetti A, Havas KM, Simeone P, Travali N, Querzoli P, Pedriali M, Roversi P, Iezzi M, Tinari N, Antolini L, Alberti S. Guerra E, et al. Among authors: havas km. Mol Cancer Ther. 2023 Jun 1;22(6):790-804. doi: 10.1158/1535-7163.MCT-22-0352. Mol Cancer Ther. 2023. PMID: 36921314
Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer.
Bacci M, Lorito N, Smiriglia A, Subbiani A, Bonechi F, Comito G, Morriset L, El Botty R, Benelli M, López-Velazco JI, Caffarel MM, Urruticoechea A, Sflomos G, Malorni L, Corsini M, Ippolito L, Giannoni E, Meattini I, Matafora V, Havas K, Bachi A, Chiarugi P, Marangoni E, Morandi A. Bacci M, et al. Sci Transl Med. 2024 Feb 28;16(736):eadf9874. doi: 10.1126/scitranslmed.adf9874. Epub 2024 Feb 28. Sci Transl Med. 2024. PMID: 38416843
Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect.
Hershey BJ, Barozzi S, Orsenigo F, Pompei S, Iannelli F, Kamrad S, Matafora V, Pisati F, Calabrese L, Fragale G, Salvadori G, Martini E, Totaro MG, Magni S, Guan R, Parazzoli D, Maiuri P, Bachi A, Patil KR, Cosentino Lagomarsino M, Havas KM. Hershey BJ, et al. Among authors: havas km. Sci Adv. 2023 Sep 15;9(37):eadh4184. doi: 10.1126/sciadv.adh4184. Epub 2023 Sep 15. Sci Adv. 2023. PMID: 37713487 Free PMC article.
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration.
Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M, Restuccia U, Matafora V, Bachi A, Barozzi S, Parazzoli D, Frittoli E, Palamidessi A, Panciera T, Piccolo S, Scita G, Maiuri P, Havas KM, Zhou ZW, Kumar A, Bartek J, Wang ZQ, Foiani M. Kidiyoor GR, et al. Among authors: havas km. Nat Commun. 2020 Sep 24;11(1):4828. doi: 10.1038/s41467-020-18580-9. Nat Commun. 2020. PMID: 32973141 Free PMC article.
Metabolic shifts in residual breast cancer drive tumor recurrence.
Havas KM, Milchevskaya V, Radic K, Alladin A, Kafkia E, Garcia M, Stolte J, Klaus B, Rotmensz N, Gibson TJ, Burwinkel B, Schneeweiss A, Pruneri G, Patil KR, Sotillo R, Jechlinger M. Havas KM, et al. J Clin Invest. 2017 Jun 1;127(6):2091-2105. doi: 10.1172/JCI89914. Epub 2017 May 15. J Clin Invest. 2017. PMID: 28504653 Free PMC article.