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Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD.
Afroz T, Chevalier E, Audrain M, Dumayne C, Ziehm T, Moser R, Egesipe AL, Mottier L, Ratnam M, Neumann M, Havas D, Ollier R, Piorkowska K, Chauhan M, Silva AB, Thapa S, Stöhr J, Bavdek A, Eligert V, Adolfsson O, Nelson PT, Porta S, Lee VM, Pfeifer A, Kosco-Vilbois M, Seredenina T. Afroz T, et al. Among authors: havas d. Neurobiol Dis. 2023 Apr;179:106050. doi: 10.1016/j.nbd.2023.106050. Epub 2023 Feb 20. Neurobiol Dis. 2023. PMID: 36809847 Free article.
Amyloid precursor protein induces reactive astrogliosis.
Velezmoro Jauregui G, Vukić D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovačovicova KL, Polakova N, Zelinkova J, Čarna M, Lacovich V, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connell MA, Rissman R, Stokin GB. Velezmoro Jauregui G, et al. Among authors: havas d. Acta Physiol (Oxf). 2024 Jun;240(6):e14142. doi: 10.1111/apha.14142. Epub 2024 Apr 8. Acta Physiol (Oxf). 2024. PMID: 38584589
Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways.
Feole M, Pozo Devoto VM, Dragišić N, Arnaiz C, Bianchelli J, Texlová K, Kovačovicova K, Novotny JS, Havas D, Falzone TL, Stokin GB. Feole M, et al. Among authors: havas d. J Biol Chem. 2024 Apr;300(4):107137. doi: 10.1016/j.jbc.2024.107137. Epub 2024 Mar 5. J Biol Chem. 2024. PMID: 38447793 Free PMC article.
Amyloid precursor protein induces reactive astrogliosis.
Jauregui GV, Vukić D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovačovicova KL, Polakova N, Zelinkova J, Čarna M, Strašil VL, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connel M, Rissman R, Stokin GB. Jauregui GV, et al. Among authors: havas d. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.571817. doi: 10.1101/2023.12.18.571817. bioRxiv. 2023. PMID: 38187544 Free PMC article. Updated. Preprint.
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S. Causevic M, et al. Among authors: havas d. PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018. PLoS One. 2018. PMID: 29979789 Free PMC article.
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.
Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL. Collier TJ, et al. Among authors: havas d. Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12. Neurobiol Dis. 2017. PMID: 28711409 Free PMC article.
30 results