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The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G. Hausmann R, et al. Mol Pharmacol. 2006 Jun;69(6):2058-67. doi: 10.1124/mol.106.022665. Epub 2006 Mar 21. Mol Pharmacol. 2006. PMID: 16551782
NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells.
Meis S, Hamacher A, Hongwiset D, Marzian C, Wiese M, Eckstein N, Royer HD, Communi D, Boeynaems JM, Hausmann R, Schmalzing G, Kassack MU. Meis S, et al. Among authors: hausmann r. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47. doi: 10.1124/jpet.109.157750. Epub 2009 Oct 8. J Pharmacol Exp Ther. 2010. PMID: 19815812
Amino acid residues constituting the agonist binding site of the human P2X3 receptor.
Bodnar M, Wang H, Riedel T, Hintze S, Kato E, Fallah G, Gröger-Arndt H, Giniatullin R, Grohmann M, Hausmann R, Schmalzing G, Illes P, Rubini P. Bodnar M, et al. Among authors: hausmann r. J Biol Chem. 2011 Jan 28;286(4):2739-49. doi: 10.1074/jbc.M110.167437. Epub 2010 Nov 22. J Biol Chem. 2011. PMID: 21098022 Free PMC article.
262 results