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Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease.
Tallon C, Bell BJ, Malvankar MM, Deme P, Nogueras-Ortiz C, Eren E, Thomas AG, Hollinger KR, Pal A, Mustapic M, Huang M, Coleman K, Joe TR, Rais R, Haughey NJ, Kapogiannis D, Slusher BS. Tallon C, et al. Among authors: haughey nj. Res Sq [Preprint]. 2023 Jul 18:rs.3.rs-3131295. doi: 10.21203/rs.3.rs-3131295/v1. Res Sq. 2023. PMID: 37502930 Free PMC article. Updated. Preprint.
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.
Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C. Figuera-Losada M, et al. Among authors: haughey nj. PLoS One. 2015 May 26;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015. PLoS One. 2015. PMID: 26010541 Free PMC article.
Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.
Nedelcovych MT, Gadiano AJ, Wu Y, Manning AA, Thomas AG, Khuder SS, Yoo SW, Xu J, McArthur JC, Haughey NJ, Volsky DJ, Rais R, Slusher BS. Nedelcovych MT, et al. Among authors: haughey nj. ACS Chem Neurosci. 2018 Apr 18;9(4):809-816. doi: 10.1021/acschemneuro.7b00434. Epub 2018 Jan 4. ACS Chem Neurosci. 2018. PMID: 29257872 Free PMC article.
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS. Rojas C, et al. Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2. Sci Rep. 2018. PMID: 30531925 Free PMC article.
A novel and potent brain penetrant inhibitor of extracellular vesicle release.
Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey NJ, Nencka R, Slusher B. Rojas C, et al. Among authors: haughey nj. Br J Pharmacol. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789. Epub 2019 Sep 4. Br J Pharmacol. 2019. PMID: 31273753 Free PMC article.
Lipidomic characterization of extracellular vesicles in human serum.
Chen S, Datta-Chaudhuri A, Deme P, Dickens A, Dastgheyb R, Bhargava P, Bi H, Haughey NJ. Chen S, et al. Among authors: haughey nj. J Circ Biomark. 2019 Sep 30;8:1849454419879848. doi: 10.1177/1849454419879848. eCollection 2019 Jan-Dec. J Circ Biomark. 2019. PMID: 31632506 Free PMC article.
172 results