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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: hattori h. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Ohashi T, Tanaka Y, Shiokawa Z, Banno H, Tanaka T, Shibata S, Satoh Y, Yamakawa H, Yamamoto Y, Hattori H, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: hattori h. Bioorg Med Chem. 2015 Aug 1;23(15):4777-4791. doi: 10.1016/j.bmc.2015.05.036. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26094943
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
Yoshikawa M, Saitoh M, Katoh T, Seki T, Bigi SV, Shimizu Y, Ishii T, Okai T, Kuno M, Hattori H, Watanabe E, Saikatendu KS, Zou H, Nakakariya M, Tatamiya T, Nakada Y, Yogo T. Yoshikawa M, et al. Among authors: hattori h. J Med Chem. 2018 Mar 22;61(6):2384-2409. doi: 10.1021/acs.jmedchem.7b01647. Epub 2018 Mar 6. J Med Chem. 2018. PMID: 29485864
A Case of Myocardial Infarction with Non-obstructive Coronary Arteries Complicated by a Ventricular Septal Rupture: The Challenge of Achieving Hemodynamic Stability Using Impella Devices.
Yokoi M, Ito T, Kawada Y, Yamamoto J, Yamada T, Kikuchi S, Kitada S, Goto T, Hattori H, Suda H, Seo Y. Yokoi M, et al. Among authors: hattori h. Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.2945-23. Online ahead of print. Intern Med. 2024. PMID: 38599873 Free article.
1,162 results