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When proteostasis goes bad: Protein aggregation in the cell.
Radwan M, Wood RJ, Sui X, Hatters DM. Radwan M, et al. Among authors: hatters dm. IUBMB Life. 2017 Feb;69(2):49-54. doi: 10.1002/iub.1597. Epub 2017 Jan 9. IUBMB Life. 2017. PMID: 28066979 Free article. Review.
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.
Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. Ramdzan YM, et al. Among authors: hatters dm. Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029. Cell Rep. 2017. PMID: 28467905 Free article.
A thiol probe for measuring unfolded protein load and proteostasis in cells.
Chen MZ, Moily NS, Bridgford JL, Wood RJ, Radwan M, Smith TA, Song Z, Tang BZ, Tilley L, Xu X, Reid GE, Pouladi MA, Hong Y, Hatters DM. Chen MZ, et al. Among authors: hatters dm. Nat Commun. 2017 Sep 7;8(1):474. doi: 10.1038/s41467-017-00203-5. Nat Commun. 2017. PMID: 28883394 Free PMC article.
A biosensor-based framework to measure latent proteostasis capacity.
Wood RJ, Ormsby AR, Radwan M, Cox D, Sharma A, Vöpel T, Ebbinghaus S, Oliveberg M, Reid GE, Dickson A, Hatters DM. Wood RJ, et al. Among authors: hatters dm. Nat Commun. 2018 Jan 18;9(1):287. doi: 10.1038/s41467-017-02562-5. Nat Commun. 2018. PMID: 29348634 Free PMC article.
82 results