Hartmann G - Search Results

1

Deficiency in coatomer complex I causes aberrant activation of STING signalling.

Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Steiner A, et al. Among authors: hartmann g. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. Nat Commun. 2022. PMID: 35484149 Free PMC article.

2

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.

Kübler K, Gehrke N, Riemann S, Böhnert V, Zillinger T, Hartmann E, Pölcher M, Rudlowski C, Kuhn W, Hartmann G, Barchet W. Kübler K, et al. Among authors: hartmann g, hartmann e. Cancer Res. 2010 Jul 1;70(13):5293-304. doi: 10.1158/0008-5472.CAN-10-0825. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551064

3

Monocyte-mediated inhibition of TLR9-dependent IFN-α induction in plasmacytoid dendritic cells questions bacterial DNA as the active ingredient of bacterial lysates.

Poth JM, Coch C, Busch N, Boehm O, Schlee M, Janke M, Zillinger T, Schildgen O, Barchet W, Hartmann G. Poth JM, et al. Among authors: hartmann g. J Immunol. 2010 Dec 15;185(12):7367-73. doi: 10.4049/jimmunol.1001798. Epub 2010 Nov 5. J Immunol. 2010. PMID: 21057083

4

Delivery with polycations extends the immunostimulant Ribomunyl into a potent antiviral Toll-like receptor 7/8 agonist.

Herberhold S, Coch C, Zillinger T, Hommertgen B, Busch N, Schuberth C, Hartmann E, Wimmenauer V, Hagmann CA, Lüdenbach B, Schlee M, Bootz F, Hartmann G, Barchet W. Herberhold S, et al. Among authors: hartmann g, hartmann e. Antivir Ther. 2011;16(5):751-8. doi: 10.3851/IMP1822. Antivir Ther. 2011. PMID: 21817197

5

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells.

Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, Jakobs C, Schuberth C, Coch C, Higgins PG, Wisplinghoff H, Barchet W, Hornung V, Hartmann G, Schlee M. Hagmann CA, et al. Among authors: hartmann g. PLoS One. 2013 Apr 30;8(4):e62872. doi: 10.1371/journal.pone.0062872. Print 2013. PLoS One. 2013. PMID: 23653683 Free PMC article.

6

Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Gao P, et al. Among authors: hartmann g. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug 1. Cell. 2013. PMID: 23910378 Free PMC article.

7

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tüting T, Hartmann G, Barchet W. Gehrke N, et al. Among authors: hartmann g. Immunity. 2013 Sep 19;39(3):482-95. doi: 10.1016/j.immuni.2013.08.004. Epub 2013 Aug 29. Immunity. 2013. PMID: 23993650 Free article.

8

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C. Goubau D, et al. Among authors: hartmann g. Nature. 2014 Oct 16;514(7522):372-375. doi: 10.1038/nature13590. Epub 2014 Aug 10. Nature. 2014. PMID: 25119032 Free PMC article.

9

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ. Gao P, et al. Among authors: hartmann g. Cell Rep. 2014 Sep 25;8(6):1668-1676. doi: 10.1016/j.celrep.2014.08.010. Epub 2014 Sep 4. Cell Rep. 2014. PMID: 25199835 Free PMC article.

10

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M. Herzner AM, et al. Among authors: hartmann g. Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. Nat Immunol. 2015. PMID: 26343537 Free PMC article.

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