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NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF. Furthmann N, et al. Among authors: hartl fu. Nat Commun. 2023 Dec 19;14(1):8368. doi: 10.1038/s41467-023-44033-0. Nat Commun. 2023. PMID: 38114471 Free PMC article.
Calmodulin regulates protease versus co-chaperone activity of a metacaspase.
Eisele-Bürger AM, Eisele F, Malmgren Hill S, Hao X, Schneider KL, Imamoglu R, Balchin D, Liu B, Hartl FU, Bozhkov PV, Nyström T. Eisele-Bürger AM, et al. Among authors: hartl fu. Cell Rep. 2023 Nov 28;42(11):113372. doi: 10.1016/j.celrep.2023.113372. Epub 2023 Nov 8. Cell Rep. 2023. PMID: 37938971 Free article.
The chaperone Clusterin in neurodegeneration-friend or foe?
Yuste-Checa P, Bracher A, Hartl FU. Yuste-Checa P, et al. Among authors: hartl fu. Bioessays. 2022 Jul;44(7):e2100287. doi: 10.1002/bies.202100287. Epub 2022 May 6. Bioessays. 2022. PMID: 35521968 Review.
Quality Control: Maintaining molecular order and preventing cellular chaos.
Neal S, Ohtake F, Cuervo AM, Hegde RS, Jakob U, Lazarou M, Gilbert WV, Chen ZJ, Tooze SA, Haber JE, Walters KJ, Hartl FU. Neal S, et al. Among authors: hartl fu. Mol Cell. 2022 Apr 21;82(8):1390-1397. doi: 10.1016/j.molcel.2022.04.002. Mol Cell. 2022. PMID: 35452608 Free article.
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D. Riemenschneider H, et al. Among authors: hartl fu. EMBO Rep. 2022 Jun 7;23(6):e53890. doi: 10.15252/embr.202153890. Epub 2022 Apr 19. EMBO Rep. 2022. PMID: 35438230 Free PMC article.
A new way of D/Ealing with protein misfolding.
Sitron CS, Hartl FU. Sitron CS, et al. Among authors: hartl fu. Mol Cell. 2021 Oct 21;81(20):4114-4115. doi: 10.1016/j.molcel.2021.09.025. Mol Cell. 2021. PMID: 34686313 Free article.
301 results