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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
Plé C, Tam HK, Vieira Da Cruz A, Compagne N, Jiménez-Castellanos JC, Müller RT, Pradel E, Foong WE, Malloci G, Ballée A, Kirchner MA, Moshfegh P, Herledan A, Herrmann A, Deprez B, Willand N, Vargiu AV, Pos KM, Flipo M, Hartkoorn RC. Plé C, et al. Among authors: hartkoorn rc. Nat Commun. 2022 Jan 10;13(1):115. doi: 10.1038/s41467-021-27726-2. Nat Commun. 2022. PMID: 35013254 Free PMC article.
Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases.
Dam S, Tangara S, Hamela C, Hattabi T, Faïon L, Carre P, Antoine R, Herledan A, Leroux F, Piveteau C, Eveque M, Flipo M, Deprez B, Kremer L, Willand N, Villemagne B, Hartkoorn RC. Dam S, et al. Among authors: hartkoorn rc. J Med Chem. 2022 Dec 22;65(24):16651-16664. doi: 10.1021/acs.jmedchem.2c01493. Epub 2022 Dec 6. J Med Chem. 2022. PMID: 36473699 Free PMC article.
Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.
Vieira Da Cruz A, Jiménez-Castellanos JC, Börnsen C, Van Maele L, Compagne N, Pradel E, Müller RT, Meurillon V, Soulard D, Piveteau C, Biela A, Dumont J, Leroux F, Deprez B, Willand N, Pos KM, Frangakis AS, Hartkoorn RC, Flipo M. Vieira Da Cruz A, et al. Among authors: hartkoorn rc. EMBO Mol Med. 2024 Jan;16(1):93-111. doi: 10.1038/s44321-023-00007-9. Epub 2023 Dec 20. EMBO Mol Med. 2024. PMID: 38177534 Free PMC article.
Pyrrolomycins Are Potent Natural Protonophores.
Valderrama K, Pradel E, Firsov AM, Drobecq H, Bauderlique-le Roy H, Villemagne B, Antonenko YN, Hartkoorn RC. Valderrama K, et al. Among authors: hartkoorn rc. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01450-19. doi: 10.1128/AAC.01450-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405863 Free PMC article.
Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters.
Temesszentandrási-Ambrus C, Tóth S, Verma R, Bánhegyi P, Szabadkai I, Baska F, Szántai-Kis C, Hartkoorn RC, Lingerfelt MA, Sarkadi B, Szakács G, Őrfi L, Nagaraja V, Ekins S, Telbisz Á. Temesszentandrási-Ambrus C, et al. Among authors: hartkoorn rc. PLoS One. 2018 Sep 5;13(9):e0202749. doi: 10.1371/journal.pone.0202749. eCollection 2018. PLoS One. 2018. PMID: 30183750 Free PMC article.
Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function.
Moureu S, Caradec T, Trivelli X, Drobecq H, Beury D, Bouquet P, Caboche S, Desmecht E, Maurier F, Muharram G, Villemagne B, Herledan A, Hot D, Willand N, Hartkoorn RC. Moureu S, et al. Among authors: hartkoorn rc. Appl Microbiol Biotechnol. 2021 Jul;105(13):5541-5551. doi: 10.1007/s00253-021-11404-w. Epub 2021 Jun 30. Appl Microbiol Biotechnol. 2021. PMID: 34189614
54 results