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Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.
Sci Adv. 2023 Jun 9;9(23):eadg0330. doi: 10.1126/sciadv.adg0330. Epub 2023 Jun 7.
Sci Adv. 2023.
PMID: 37285422
Free PMC article.
Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.
Harshbarger W, Tian S, Wahome N, Balsaraf A, Bhattacharya D, Jiang D, Pandey R, Tungare K, Friedrich K, Mehzabeen N, Biancucci M, Chinchilla-Olszar D, Mallett CP, Huang Y, Wang Z, Bottomley MJ, Malito E, Chandramouli S.
Harshbarger W, et al.
PLoS Pathog. 2020 Nov 2;16(11):e1008943. doi: 10.1371/journal.ppat.1008943. eCollection 2020 Nov.
PLoS Pathog. 2020.
PMID: 33137810
Free PMC article.
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Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Harshbarger W, Abeyrathne PD, Tian S, Huang Y, Chandramouli S, Bottomley MJ, Malito E.
Harshbarger W, et al.
MAbs. 2021 Jan-Dec;13(1):1955812. doi: 10.1080/19420862.2021.1955812.
MAbs. 2021.
PMID: 34420474
Free PMC article.
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Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS.
Ferguson FM, et al.
Nat Chem Biol. 2020 Jun;16(6):635-643. doi: 10.1038/s41589-020-0506-0. Epub 2020 Apr 6.
Nat Chem Biol. 2020.
PMID: 32251410
Free PMC article.
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Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Harshbarger WD, Deming D, Lockbaum GJ, Attatippaholkun N, Kamkaew M, Hou S, Somasundaran M, Wang JP, Finberg RW, Zhu QK, Schiffer CA, Marasco WA.
Harshbarger WD, et al.
Nat Commun. 2021 Jan 25;12(1):559. doi: 10.1038/s41467-020-20879-6.
Nat Commun. 2021.
PMID: 33495478
Free PMC article.
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A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.
Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, Sacchettini JC, Liu WR, Sieber SA, Smith JW, Romo D.
Zhu M, et al. Among authors: harshbarger wd.
Bioorg Med Chem. 2017 Jun 1;25(11):2901-2916. doi: 10.1016/j.bmc.2017.01.020. Epub 2017 Jan 19.
Bioorg Med Chem. 2017.
PMID: 28236510
Free PMC article.
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