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Page 1
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Among authors: harrison r. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Mainolfi N, Ehara T, Karki RG, Anderson K, Mac Sweeney A, Liao SM, Argikar UA, Jendza K, Zhang C, Powers J, Klosowski DW, Crowley M, Kawanami T, Ding J, April M, Forster C, Serrano-Wu M, Capparelli M, Ramqaj R, Solovay C, Cumin F, Smith TM, Ferrara L, Lee W, Long D, Prentiss M, De Erkenez A, Yang L, Liu F, Sellner H, Sirockin F, Valeur E, Erbel P, Ostermeier D, Ramage P, Gerhartz B, Schubart A, Flohr S, Gradoux N, Feifel R, Vogg B, Wiesmann C, Maibaum J, Eder J, Sedrani R, Harrison RA, Mogi M, Jaffee BD, Adams CM. Mainolfi N, et al. Among authors: harrison ra. J Med Chem. 2020 Jun 11;63(11):5697-5722. doi: 10.1021/acs.jmedchem.9b01870. Epub 2020 Feb 19. J Med Chem. 2020. PMID: 32073845
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K. Maibaum J, et al. Among authors: harrison r. Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24. Nat Chem Biol. 2016. PMID: 27775713
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
Ripa L, Edman K, Dearman M, Edenro G, Hendrickx R, Ullah V, Chang HF, Lepistö M, Chapman D, Geschwindner S, Wissler L, Svanberg P, Lawitz K, Malmberg J, Nikitidis A, Olsson RI, Bird J, Llinas A, Hegelund-Myrbäck T, Berger M, Thorne P, Harrison R, Köhler C, Drmota T. Ripa L, et al. Among authors: harrison r. J Med Chem. 2018 Mar 8;61(5):1785-1799. doi: 10.1021/acs.jmedchem.7b01690. Epub 2018 Feb 16. J Med Chem. 2018. PMID: 29424542
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV. Cheshire DR, et al. Among authors: harrison r. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18. Bioorg Med Chem Lett. 2011. PMID: 21398123
Co-designing strategies to improve advance care planning among people from culturally and linguistically diverse backgrounds with cancer: iCanCarePlan study protocol.
Chauhan A, Chitkara U, Walsan R, Sansom-Daly UM, Manias E, Seah D, Dalli A, El-Kabbout N, Tieu T, Sarwar M, Faiz M, Huang N, Rocha VM, Pal A, Harrison R. Chauhan A, et al. Among authors: harrison r. BMC Palliat Care. 2024 May 18;23(1):123. doi: 10.1186/s12904-024-01453-z. BMC Palliat Care. 2024. PMID: 38760714 Free PMC article.
Psychodynamic Bootcamp: From Theory to Practice.
Harrison R, Hickey C. Harrison R, et al. Acad Psychiatry. 2024 May 15. doi: 10.1007/s40596-024-01982-y. Online ahead of print. Acad Psychiatry. 2024. PMID: 38750306 No abstract available.
Managing Implanted Cardiac Electronic Devices in Patients With Severe Tricuspid Regurgitation: JACC State-of-the-Art Review.
Hahn RT, Wilkoff BL, Kodali S, Birgersdotter-Green UM, Ailawadi G, Addetia K, Andreas M, Auricchio A, Ehlert F, George I, Gupta A, Harrison R, Ho EC, Kusumoto F, Latib A, O'Gara P, Patton KK, Pinney S, Zeitler EP, Mack MJ, Leon MB, Epstein LM; Heart Valve Collaboratory and Heart Rhythm Society. Hahn RT, et al. Among authors: harrison r. J Am Coll Cardiol. 2024 May 21;83(20):2002-2014. doi: 10.1016/j.jacc.2024.02.045. J Am Coll Cardiol. 2024. PMID: 38749619 Review.
Regional impact assessment of air quality improvement: The air quality lifecourse assessment tool (AQ-LAT) for the West Midlands combined authority (WMCA).
Hall J, Zhong J, Jowett S, Mazzeo A, Thomas GN, Bryson JR, Dewar S, Inglis N, Wolstencroft M, Muller C, Bloss W, Harrison R, Bartington S. Hall J, et al. Among authors: harrison r. Environ Pollut. 2024 Apr 29:123871. doi: 10.1016/j.envpol.2024.123871. Online ahead of print. Environ Pollut. 2024. PMID: 38729507 Free article.
4,066 results