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Noncoding regions are the main source of targetable tumor-specific antigens.
Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault C. Laumont CM, et al. Among authors: hardy mp. Sci Transl Med. 2018 Dec 5;10(470):eaau5516. doi: 10.1126/scitranslmed.aau5516. Sci Transl Med. 2018. PMID: 30518613
The MHC class I peptide repertoire is molded by the transcriptome.
Fortier MH, Caron E, Hardy MP, Voisin G, Lemieux S, Perreault C, Thibault P. Fortier MH, et al. Among authors: hardy mp. J Exp Med. 2008 Mar 17;205(3):595-610. doi: 10.1084/jem.20071985. Epub 2008 Feb 25. J Exp Med. 2008. PMID: 18299400 Free PMC article.
ER stress affects processing of MHC class I-associated peptides.
Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C. Granados DP, et al. Among authors: hardy mp. BMC Immunol. 2009 Feb 16;10:10. doi: 10.1186/1471-2172-10-10. BMC Immunol. 2009. PMID: 19220912 Free PMC article.
Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules.
de Verteuil D, Muratore-Schroeder TL, Granados DP, Fortier MH, Hardy MP, Bramoullé A, Caron E, Vincent K, Mader S, Lemieux S, Thibault P, Perreault C. de Verteuil D, et al. Among authors: hardy mp. Mol Cell Proteomics. 2010 Sep;9(9):2034-47. doi: 10.1074/mcp.M900566-MCP200. Epub 2010 May 19. Mol Cell Proteomics. 2010. PMID: 20484733 Free PMC article.
Rejection of leukemic cells requires antigen-specific T cells with high functional avidity.
Vincent K, Hardy MP, Trofimov A, Laumont CM, Sriranganadane D, Hadj-Mimoune S, Salem Fourati I, Soudeyns H, Thibault P, Perreault C. Vincent K, et al. Among authors: hardy mp. Biol Blood Marrow Transplant. 2014 Jan;20(1):37-45. doi: 10.1016/j.bbmt.2013.10.020. Epub 2013 Oct 23. Biol Blood Marrow Transplant. 2014. PMID: 24161924 Free article.
174 results