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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Lang J, et al. Among authors: hardt c. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8. Nat Commun. 2020. PMID: 32165633 Free PMC article.
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. Khairnar V, et al. Among authors: hardt c. Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217. Nat Commun. 2015. PMID: 25692415 Free PMC article.
CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.
Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. Khairnar V, et al. Among authors: hardt c. Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2. Nat Commun. 2018. PMID: 29967450 Free PMC article.
CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection.
Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS. Shaabani N, et al. Among authors: hardt c. Cell Death Dis. 2016 Nov 3;7(11):e2446. doi: 10.1038/cddis.2016.350. Cell Death Dis. 2016. PMID: 27809306 Free PMC article.
Interferon in the CNS.
Bhat H, Lang KS, Hardt C, Lang J. Bhat H, et al. Among authors: hardt c. Neurosignals. 2019;27(S1):44-53. doi: 10.33594/000000197. Neurosignals. 2019. PMID: 31865647 Free article. Review.
98 results