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RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. Zimmermann TS, et al. Among authors: harborth j. Nature. 2006 May 4;441(7089):111-4. doi: 10.1038/nature04688. Epub 2006 Mar 26. Nature. 2006. PMID: 16565705
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Soutschek J, et al. Among authors: harborth j. Nature. 2004 Nov 11;432(7014):173-8. doi: 10.1038/nature03121. Nature. 2004. PMID: 15538359 Free article.
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).
DeVincenzo J, Cehelsky JE, Alvarez R, Elbashir S, Harborth J, Toudjarska I, Nechev L, Murugaiah V, Van Vliet A, Vaishnaw AK, Meyers R. DeVincenzo J, et al. Among authors: harborth j. Antiviral Res. 2008 Mar;77(3):225-31. doi: 10.1016/j.antiviral.2007.11.009. Epub 2007 Dec 26. Antiviral Res. 2008. PMID: 18242722 Clinical Trial.
RNAi therapeutics: an update on delivery.
Nguyen T, Menocal EM, Harborth J, Fruehauf JH. Nguyen T, et al. Among authors: harborth j. Curr Opin Mol Ther. 2008 Apr;10(2):158-67. Curr Opin Mol Ther. 2008. PMID: 18386228 Review.
Analysis of mammalian gene function using small interfering RNAs.
Martinez J, Patkaniowska A, Elbashir SM, Harborth J, Hossbach M, Urlaub H, Meyer J, Weber K, Vandenburgh K, Manninga H, Scaringe SA, Luehrmann R, Tuschl T. Martinez J, et al. Among authors: harborth j. Nucleic Acids Res Suppl. 2003;(3):333. doi: 10.1093/nass/3.1.333. Nucleic Acids Res Suppl. 2003. PMID: 14510516 No abstract available.
23 results