Hansen DA - Search Results

1

Nonribosomal biosynthesis of backbone-modified peptides.

Niquille DL, Hansen DA, Mori T, Fercher D, Kries H, Hilvert D. Niquille DL, et al. Among authors: hansen da. Nat Chem. 2018 Mar;10(3):282-287. doi: 10.1038/nchem.2891. Epub 2017 Nov 20. Nat Chem. 2018. PMID: 29461527

2

Evolution of a highly active and enantiospecific metalloenzyme from short peptides.

Studer S, Hansen DA, Pianowski ZL, Mittl PRE, Debon A, Guffy SL, Der BS, Kuhlman B, Hilvert D. Studer S, et al. Among authors: hansen da. Science. 2018 Dec 14;362(6420):1285-1288. doi: 10.1126/science.aau3744. Science. 2018. PMID: 30545884

3

High-throughput reprogramming of an NRPS condensation domain.

Folger IB, Frota NF, Pistofidis A, Niquille DL, Hansen DA, Schmeing TM, Hilvert D. Folger IB, et al. Among authors: hansen da. Nat Chem Biol. 2024 Feb 2. doi: 10.1038/s41589-023-01532-x. Online ahead of print. Nat Chem Biol. 2024. PMID: 38308044

4

Structure of a modular polyketide synthase.

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Dutta S, et al. Among authors: hansen da. Nature. 2014 Jun 26;510(7506):512-7. doi: 10.1038/nature13423. Epub 2014 Jun 18. Nature. 2014. PMID: 24965652 Free PMC article.

5

Structural rearrangements of a polyketide synthase module during its catalytic cycle.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Whicher JR, et al. Among authors: hansen da. Nature. 2014 Jun 26;510(7506):560-4. doi: 10.1038/nature13409. Epub 2014 Jun 18. Nature. 2014. PMID: 24965656 Free PMC article.

6

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Whicher JR, et al. Among authors: hansen da. Chem Biol. 2013 Nov 21;20(11):1340-51. doi: 10.1016/j.chembiol.2013.09.015. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183970 Free PMC article.

7

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.

Koch AA, Schmidt JJ, Lowell AN, Hansen DA, Coburn KM, Chemler JA, Sherman DH. Koch AA, et al. Among authors: hansen da. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13575-13580. doi: 10.1002/anie.202004991. Epub 2020 Jun 5. Angew Chem Int Ed Engl. 2020. PMID: 32357274 Free PMC article.

8

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.

Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Koryakina I, et al. Among authors: hansen da. ACS Chem Biol. 2017 Jan 20;12(1):114-123. doi: 10.1021/acschembio.6b00732. Epub 2016 Nov 29. ACS Chem Biol. 2017. PMID: 28103677 Free PMC article.

9

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.

Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS. Almutairi MM, et al. Among authors: hansen da. Nucleic Acids Res. 2017 Sep 19;45(16):9573-9582. doi: 10.1093/nar/gkx673. Nucleic Acids Res. 2017. PMID: 28934499 Free PMC article.

10

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH. Koch AA, et al. Among authors: hansen da. J Am Chem Soc. 2017 Sep 27;139(38):13456-13465. doi: 10.1021/jacs.7b06436. Epub 2017 Sep 19. J Am Chem Soc. 2017. PMID: 28836768 Free PMC article.

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