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Page 1
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.
Laurila PP, Wohlwend M, Imamura de Lima T, Luan P, Herzig S, Zanou N, Crisol B, Bou-Sleiman M, Porcu E, Gallart-Ayala H, Handzlik MK, Wang Q, Jain S, D'Amico D, Salonen M, Metallo CM, Kutalik Z, Eichmann TO, Place N, Ivanisevic J, Lahti J, Eriksson JG, Auwerx J. Laurila PP, et al. Among authors: handzlik mk. Nat Aging. 2022 Dec;2(12):1159-1175. doi: 10.1038/s43587-022-00309-6. Epub 2022 Dec 16. Nat Aging. 2022. PMID: 37118545
Serine restriction alters sphingolipid diversity to constrain tumour growth.
Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, Saghatelian A, Metallo CM. Muthusamy T, et al. Among authors: handzlik mk. Nature. 2020 Oct;586(7831):790-795. doi: 10.1038/s41586-020-2609-x. Epub 2020 Aug 12. Nature. 2020. PMID: 32788725 Free PMC article.
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. Handzlik MK, et al. Nature. 2023 Feb;614(7946):118-124. doi: 10.1038/s41586-022-05637-6. Epub 2023 Jan 25. Nature. 2023. PMID: 36697822 Free PMC article.
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE. Gheller BJ, et al. Among authors: handzlik mk. Mol Metab. 2021 Jan;43:101106. doi: 10.1016/j.molmet.2020.101106. Epub 2020 Oct 23. Mol Metab. 2021. PMID: 33122122 Free PMC article.
Cryptochromes Suppress HIF1α in Muscles.
Vaughan ME, Wallace M, Handzlik MK, Chan AB, Metallo CM, Lamia KA. Vaughan ME, et al. Among authors: handzlik mk. iScience. 2020 Jul 24;23(7):101338. doi: 10.1016/j.isci.2020.101338. Epub 2020 Jul 3. iScience. 2020. PMID: 32683313 Free PMC article.
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle.
Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, Yu RT, Liddle C, Downes M, Delezie J, Mello R, Chan AB, Westermark PO, Metallo CM, Evans RM, Lamia KA. Casanova-Vallve N, et al. Among authors: handzlik mk. Mol Metab. 2022 Jul;61:101504. doi: 10.1016/j.molmet.2022.101504. Epub 2022 Apr 22. Mol Metab. 2022. PMID: 35470095 Free PMC article.
Tolerance to graded dosages of histidine supplementation in healthy human adults.
Gheller ME, Vermeylen F, Handzlik MK, Gheller BJ, Bender E, Metallo C, Aydemir TB, Smriga M, Thalacker-Mercer AE. Gheller ME, et al. Among authors: handzlik mk. Am J Clin Nutr. 2020 Nov 11;112(5):1358-1367. doi: 10.1093/ajcn/nqaa210. Am J Clin Nutr. 2020. PMID: 32766885 Free article. Clinical Trial.
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
Gantner ML, Eade K, Wallace M, Handzlik MK, Fallon R, Trombley J, Bonelli R, Giles S, Harkins-Perry S, Heeren TFC, Sauer L, Ideguchi Y, Baldini M, Scheppke L, Dorrell MI, Kitano M, Hart BJ, Cai C, Nagasaki T, Badur MG, Okada M, Woods SM, Egan C, Gillies M, Guymer R, Eichler F, Bahlo M, Fruttiger M, Allikmets R, Bernstein PS, Metallo CM, Friedlander M. Gantner ML, et al. Among authors: handzlik mk. N Engl J Med. 2019 Oct 10;381(15):1422-1433. doi: 10.1056/NEJMoa1815111. Epub 2019 Sep 11. N Engl J Med. 2019. PMID: 31509666 Free PMC article.
18 results