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Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Among authors: handon r. Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209400 Free PMC article.
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.
Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL. Preite S, et al. Among authors: handon r. Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20. Nat Immunol. 2018. PMID: 30127432 Free PMC article.
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cannons JL, Villarino AV, Kapnick SM, Preite S, Shih HY, Gomez-Rodriguez J, Kaul Z, Shibata H, Reilley JM, Huang B, Handon R, McBain IT, Gossa S, Wu T, Su HC, McGavern DB, O'Shea JJ, McGuire PJ, Uzel G, Schwartzberg PL. Cannons JL, et al. Among authors: handon r. Cell Rep. 2021 Oct 12;37(2):109804. doi: 10.1016/j.celrep.2021.109804. Cell Rep. 2021. PMID: 34644563 Free PMC article.
Early Th1 cell differentiation is marked by a Tfh cell-like transition.
Nakayamada S, Kanno Y, Takahashi H, Jankovic D, Lu KT, Johnson TA, Sun HW, Vahedi G, Hakim O, Handon R, Schwartzberg PL, Hager GL, O'Shea JJ. Nakayamada S, et al. Among authors: handon r. Immunity. 2011 Dec 23;35(6):919-31. doi: 10.1016/j.immuni.2011.11.012. Immunity. 2011. PMID: 22195747 Free PMC article.
Mg2+ regulation of kinase signaling and immune function.
Kanellopoulou C, George AB, Masutani E, Cannons JL, Ravell JC, Yamamoto TN, Smelkinson MG, Jiang PD, Matsuda-Lennikov M, Reilley J, Handon R, Lee PH, Miller JR, Restifo NP, Zheng L, Schwartzberg PL, Young M, Lenardo MJ. Kanellopoulou C, et al. Among authors: handon r. J Exp Med. 2019 Aug 5;216(8):1828-1842. doi: 10.1084/jem.20181970. Epub 2019 Jun 13. J Exp Med. 2019. PMID: 31196981 Free PMC article.
11 results