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Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Sekimata K, Sato T, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Honma T, Tanaka A, Shirouzu M, Yokoyama S, Miyazono K, Hashizume Y, Koyama H. Sekimata K, et al. Among authors: handa n. Chem Pharm Bull (Tokyo). 2019;67(3):224-235. doi: 10.1248/cpb.c18-00598. Chem Pharm Bull (Tokyo). 2019. PMID: 30828000 Free article.
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
Sato T, Sekimata K, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Tanaka A, Shirouzu M, Yokoyama S, Hashizume Y, Miyazono K, Koyama H, Honma T. Sato T, et al. Among authors: handa n. ACS Omega. 2020 May 12;5(20):11411-11423. doi: 10.1021/acsomega.9b04245. eCollection 2020 May 26. ACS Omega. 2020. PMID: 32478230 Free PMC article.
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.
Parker LJ, Watanabe H, Tsuganezawa K, Tomabechi Y, Handa N, Shirouzu M, Yuki H, Honma T, Ogawa N, Nagano T, Yokoyama S, Tanaka A. Parker LJ, et al. Among authors: handa n. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):860-6. doi: 10.1107/S1744309112027108. Epub 2012 Jul 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22869110 Free PMC article.
Crystal structures of the S6K1 kinase domain in complexes with inhibitors.
Niwa H, Mikuni J, Sasaki S, Tomabechi Y, Honda K, Ikeda M, Ohsawa N, Wakiyama M, Handa N, Shirouzu M, Honma T, Tanaka A, Yokoyama S. Niwa H, et al. Among authors: handa n. J Struct Funct Genomics. 2014 Sep;15(3):153-64. doi: 10.1007/s10969-014-9188-8. Epub 2014 Jul 31. J Struct Funct Genomics. 2014. PMID: 25078151 Free PMC article.
A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.
Tsuganezawa K, Watanabe H, Parker L, Yuki H, Taruya S, Nakagawa Y, Kamei D, Mori M, Ogawa N, Tomabechi Y, Handa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A. Tsuganezawa K, et al. Among authors: handa n. J Mol Biol. 2012 Mar 30;417(3):240-52. doi: 10.1016/j.jmb.2012.01.036. Epub 2012 Jan 30. J Mol Biol. 2012. PMID: 22306408
Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Handa N, et al. Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):480-7. doi: 10.1107/S0907444911010201. Epub 2011 Apr 14. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21543851
275 results