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Targeting cartilage EGFR pathway for osteoarthritis treatment.
Wei Y, Luo L, Gui T, Yu F, Yan L, Yao L, Zhong L, Yu W, Han B, Patel JM, Liu JF, Beier F, Levin LS, Nelson C, Shao Z, Han L, Mauck RL, Tsourkas A, Ahn J, Cheng Z, Qin L. Wei Y, et al. Among authors: han b, han l. Sci Transl Med. 2021 Jan 13;13(576):eabb3946. doi: 10.1126/scitranslmed.abb3946. Sci Transl Med. 2021. PMID: 33441426 Free PMC article.
Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.
Candela ME, Wang C, Gunawardena AT, Zhang K, Cantley L, Yasuhara R, Usami Y, Francois N, Iwamoto M, van der Flier A, Zhang Y, Qin L, Han L, Enomoto-Iwamoto M. Candela ME, et al. Among authors: han l. PLoS One. 2016 Jun 9;11(6):e0156783. doi: 10.1371/journal.pone.0156783. eCollection 2016. PLoS One. 2016. PMID: 27280771 Free PMC article.
EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation.
Jia H, Ma X, Tong W, Doyran B, Sun Z, Wang L, Zhang X, Zhou Y, Badar F, Chandra A, Lu XL, Xia Y, Han L, Enomoto-Iwamoto M, Qin L. Jia H, et al. Among authors: han l. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14360-14365. doi: 10.1073/pnas.1608938113. Epub 2016 Nov 28. Proc Natl Acad Sci U S A. 2016. PMID: 27911782 Free PMC article.
Intermittent Parathyroid Hormone After Prolonged Alendronate Treatment Induces Substantial New Bone Formation and Increases Bone Tissue Heterogeneity in Ovariectomized Rats.
Altman-Singles AR, Jeong Y, Tseng WJ, de Bakker CM, Zhao H, Lott C, Robberts J, Qin L, Han L, Kim DG, Liu XS. Altman-Singles AR, et al. Among authors: han l. J Bone Miner Res. 2017 Aug;32(8):1703-1715. doi: 10.1002/jbmr.3165. Epub 2017 Jun 13. J Bone Miner Res. 2017. PMID: 28467646 Free PMC article.
Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis.
Jia H, Ma X, Wei Y, Tong W, Tower RJ, Chandra A, Wang L, Sun Z, Yang Z, Badar F, Zhang K, Tseng WJ, Kramer I, Kneissel M, Xia Y, Liu XS, Wang JHC, Han L, Enomoto-Iwamoto M, Qin L. Jia H, et al. Among authors: han l. Arthritis Rheumatol. 2018 Feb;70(2):230-241. doi: 10.1002/art.40351. Epub 2017 Dec 29. Arthritis Rheumatol. 2018. PMID: 29024567 Free PMC article.
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