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Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.
Kim HS, Ortiz D, Kadayat TM, Fargo CM, Hammill JT, Chen Y, Rice AL, Begley KL, Shoeran G, Pistel W, Yates PA, Sanchez MA, Landfear SM, Guy RK. Kim HS, et al. Among authors: hammill jt. J Med Chem. 2023 Jun 8;66(11):7374-7386. doi: 10.1021/acs.jmedchem.3c00056. Epub 2023 May 22. J Med Chem. 2023. PMID: 37216489 Free article.
Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.
Gaur AH, Panetta JC, Smith AM, Dallas RH, Freeman BB 3rd, Stewart TB, Tang L, John E, Branum KC, Patel ND, Ost S, Heine RN, Richardson JL, Hammill JT, Bebrevska L, Gusovsky F, Maki N, Yanagi T, Flynn PM, McCarthy JS, Chalon S, Guy RK. Gaur AH, et al. Among authors: hammill jt. EBioMedicine. 2022 Jun;80:104065. doi: 10.1016/j.ebiom.2022.104065. Epub 2022 May 19. EBioMedicine. 2022. PMID: 35598441 Free PMC article. Clinical Trial.
Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, Landfear SM, Guy RK. Hammill JT, et al. J Med Chem. 2021 Aug 26;64(16):12152-12162. doi: 10.1021/acs.jmedchem.1c00813. Epub 2021 Aug 6. J Med Chem. 2021. PMID: 34355566 Free PMC article.
Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives.
Eagon S, Hammill JT, Fitzsimmons K, Sienko N, Nguyen B, Law J, Manjunath A, Wilkinson SP, Thompson K, Glidden JE, Rice AL, Falade MO, Kimball JJ, DiBernardo C, Guy RK. Eagon S, et al. Among authors: hammill jt. Bioorg Med Chem Lett. 2021 Sep 1;47:128216. doi: 10.1016/j.bmcl.2021.128216. Epub 2021 Jun 19. Bioorg Med Chem Lett. 2021. PMID: 34157390 Free article.
23 results