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Structure and Function in Antimicrobial Piscidins: Histidine Position, Directionality of Membrane Insertion, and pH-Dependent Permeabilization.
Mihailescu M, Sorci M, Seckute J, Silin VI, Hammer J, Perrin BS Jr, Hernandez JI, Smajic N, Shrestha A, Bogardus KA, Greenwood AI, Fu R, Blazyk J, Pastor RW, Nicholson LK, Belfort G, Cotten ML. Mihailescu M, et al. Among authors: hammer j. J Am Chem Soc. 2019 Jun 26;141(25):9837-9853. doi: 10.1021/jacs.9b00440. Epub 2019 Jun 13. J Am Chem Soc. 2019. PMID: 31144503 Free PMC article.
Complementary Effects of Host Defense Peptides Piscidin 1 and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities.
Hayden RM, Goldberg GK, Ferguson BM, Schoeneck MW, Libardo MD, Mayeux SE, Shrestha A, Bogardus KA, Hammer J, Pryshchep S, Lehman HK, McCormick ML, Blazyk J, Angeles-Boza AM, Fu R, Cotten ML. Hayden RM, et al. Among authors: hammer j. J Phys Chem B. 2015 Dec 10;119(49):15235-46. doi: 10.1021/acs.jpcb.5b09685. Epub 2015 Dec 1. J Phys Chem B. 2015. PMID: 26569483
The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.
Comert F, Greenwood A, Maramba J, Acevedo R, Lucas L, Kulasinghe T, Cairns LS, Wen Y, Fu R, Hammer J, Blazyk J, Sukharev S, Cotten ML, Mihailescu M. Comert F, et al. Among authors: hammer j. J Biol Chem. 2019 Dec 6;294(49):18557-18570. doi: 10.1074/jbc.RA119.010232. Epub 2019 Oct 16. J Biol Chem. 2019. PMID: 31619519 Free PMC article.
Antimicrobial activities and structures of two linear cationic peptide families with various amphipathic beta-sheet and alpha-helical potentials.
Jin Y, Hammer J, Pate M, Zhang Y, Zhu F, Zmuda E, Blazyk J. Jin Y, et al. Among authors: hammer j. Antimicrob Agents Chemother. 2005 Dec;49(12):4957-64. doi: 10.1128/AAC.49.12.4957-4964.2005. Antimicrob Agents Chemother. 2005. PMID: 16304158 Free PMC article.
In comparison to a 21-residue amphipathic alpha-helical peptide of equal charge and hydrophobicity, this peptide possessed more similar antimicrobial activity and greater selectivity in binding to and inducing leakage in vesicles composed of bacterial membrane lipids than vesicle …
In comparison to a 21-residue amphipathic alpha-helical peptide of equal charge and hydrophobicity, this peptide possessed more similar anti …
1,139 results