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Modeling alcohol-associated liver disease in a human Liver-Chip.
Nawroth JC, Petropolis DB, Manatakis DV, Maulana TI, Burchett G, Schlünder K, Witt A, Shukla A, Kodella K, Ronxhi J, Kulkarni G, Hamilton G, Seki E, Lu S, Karalis KC. Nawroth JC, et al. Cell Rep. 2021 Jul 20;36(3):109393. doi: 10.1016/j.celrep.2021.109393. Cell Rep. 2021. PMID: 34289365 Free PMC article.
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.
Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Kasendra M, et al. Among authors: hamilton ga. Elife. 2020 Jan 14;9:e50135. doi: 10.7554/eLife.50135. Elife. 2020. PMID: 31933478 Free PMC article.
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability.
Apostolou A, Panchakshari RA, Banerjee A, Manatakis DV, Paraskevopoulou MD, Luc R, Abu-Ali G, Dimitriou A, Lucchesi C, Kulkarni G, Maulana TI, Kasendra M, Kerns JS, Bleck B, Ewart L, Manolakos ES, Hamilton GA, Giallourakis C, Karalis K. Apostolou A, et al. Among authors: hamilton ga. Cell Mol Gastroenterol Hepatol. 2021;12(5):1719-1741. doi: 10.1016/j.jcmgh.2021.07.004. Epub 2021 Jul 17. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34284165 Free PMC article.
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: hamilton ga. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927
Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
Kerns SJ, Belgur C, Petropolis D, Kanellias M, Barrile R, Sam J, Weinzierl T, Fauti T, Freimoser-Grundschober A, Eckmann J, Hage C, Geiger M, Ng PR, Tien-Street W, Manatakis DV, Micallef V, Gerard R, Bscheider M, Breous-Nystrom E, Schneider A, Giusti AM, Bertinetti-Lapatki C, Grant HS, Roth AB, Hamilton GA, Singer T, Karalis K, Moisan A, Bruenker P, Klein C, Bacac M, Gjorevski N, Cabon L. Kerns SJ, et al. Among authors: hamilton ga. Elife. 2021 Aug 11;10:e67106. doi: 10.7554/eLife.67106. Elife. 2021. PMID: 34378534 Free PMC article.
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Foster AJ, Chouhan B, Regan SL, Rollison H, Amberntsson S, Andersson LC, Srivastava A, Darnell M, Cairns J, Lazic SE, Jang KJ, Petropolis DB, Kodella K, Rubins JE, Williams D, Hamilton GA, Ewart L, Morgan P. Foster AJ, et al. Among authors: hamilton ga. Arch Toxicol. 2019 Apr;93(4):1021-1037. doi: 10.1007/s00204-019-02427-4. Epub 2019 Mar 26. Arch Toxicol. 2019. PMID: 30915487
146 results