Hamel E - Search Results

1

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.

Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. Among authors: hamel e. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.

2

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

3

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

Muzaffar A, Brossi A, Lin CM, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Med Chem. 1990 Feb;33(2):567-71. doi: 10.1021/jm00164a015. J Med Chem. 1990. PMID: 2299625

4

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

Cushman M, He HM, Katzenellenbogen JA, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1995 Jun 9;38(12):2041-9. doi: 10.1021/jm00012a003. J Med Chem. 1995. PMID: 7783135

5

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

Li L, Wang HK, Kuo SC, Wu TS, Mauger A, Lin CM, Hamel E, Lee KH. Li L, et al. Among authors: hamel e. J Med Chem. 1994 Sep 30;37(20):3400-7. doi: 10.1021/jm00046a025. J Med Chem. 1994. PMID: 7932568

6

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

Kuo SC, Lee HZ, Juang JP, Lin YT, Wu TS, Chang JJ, Lednicer D, Paull KD, Lin CM, Hamel E, et al. Kuo SC, et al. Among authors: hamel e. J Med Chem. 1993 Apr 30;36(9):1146-56. doi: 10.1021/jm00061a005. J Med Chem. 1993. PMID: 8387598

7

Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.

Cushman M, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1993 Sep 17;36(19):2817-21. doi: 10.1021/jm00071a012. J Med Chem. 1993. PMID: 8410995

8

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

Sun L, McPhail AT, Hamel E, Lin CM, Hastie SB, Chang JJ, Lee KH. Sun L, et al. Among authors: hamel e. J Med Chem. 1993 Mar 5;36(5):544-51. doi: 10.1021/jm00057a004. J Med Chem. 1993. PMID: 8496935

9

Synthesis and biological activity of A-nor-paclitaxel analogues.

Chordia MD, Kingston DG, Hamel E, Lin CM, Long BH, Fairchild CA, Johnston KA, Rose WC. Chordia MD, et al. Among authors: hamel e. Bioorg Med Chem. 1997 May;5(5):941-7. doi: 10.1016/s0968-0896(97)00035-7. Bioorg Med Chem. 1997. PMID: 9208103

10

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, Hamel E, Lee KH. Chen K, et al. Among authors: hamel e. J Med Chem. 1997 Jul 4;40(14):2266-75. doi: 10.1021/jm960858s. J Med Chem. 1997. PMID: 9216846

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