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The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.
Barut GT, Halwe NJ, Taddeo A, Kelly JN, Schön J, Ebert N, Ulrich L, Devisme C, Steiner S, Trüeb BS, Hoffmann B, Veiga IB, Leborgne NGF, Moreira EA, Breithaupt A, Wylezich C, Höper D, Wernike K, Godel A, Thomann L, Flück V, Stalder H, Brügger M, Esteves BIO, Zumkehr B, Beilleau G, Kratzel A, Schmied K, Ochsenbein S, Lang RM, Wider M, Machahua C, Dorn P, Marti TM, Funke-Chambour M, Rauch A, Widera M, Ciesek S, Dijkman R, Hoffmann D, Alves MP, Benarafa C, Beer M, Thiel V. Barut GT, et al. Among authors: halwe nj. Nat Commun. 2022 Oct 7;13(1):5929. doi: 10.1038/s41467-022-33632-y. Nat Commun. 2022. PMID: 36207334 Free PMC article.
SARS-CoV-2 spike D614G change enhances replication and transmission.
Zhou B, Thao TTN, Hoffmann D, Taddeo A, Ebert N, Labroussaa F, Pohlmann A, King J, Steiner S, Kelly JN, Portmann J, Halwe NJ, Ulrich L, Trüeb BS, Fan X, Hoffmann B, Wang L, Thomann L, Lin X, Stalder H, Pozzi B, de Brot S, Jiang N, Cui D, Hossain J, Wilson MM, Keller MW, Stark TJ, Barnes JR, Dijkman R, Jores J, Benarafa C, Wentworth DE, Thiel V, Beer M. Zhou B, et al. Among authors: halwe nj. Nature. 2021 Apr;592(7852):122-127. doi: 10.1038/s41586-021-03361-1. Epub 2021 Feb 26. Nature. 2021. PMID: 33636719
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2.
Hoffmann D, Corleis B, Rauch S, Roth N, Mühe J, Halwe NJ, Ulrich L, Fricke C, Schön J, Kraft A, Breithaupt A, Wernike K, Michelitsch A, Sick F, Wylezich C, Hoffmann B, Thran M, Thess A, Mueller SO, Mettenleiter TC, Petsch B, Dorhoi A, Beer M. Hoffmann D, et al. Among authors: halwe nj. Nat Commun. 2021 Jun 30;12(1):4048. doi: 10.1038/s41467-021-24339-7. Nat Commun. 2021. PMID: 34193869 Free PMC article.
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.
Ulrich L, Halwe NJ, Taddeo A, Ebert N, Schön J, Devisme C, Trüeb BS, Hoffmann B, Wider M, Fan X, Bekliz M, Essaidi-Laziosi M, Schmidt ML, Niemeyer D, Corman VM, Kraft A, Godel A, Laloli L, Kelly JN, Calderon BM, Breithaupt A, Wylezich C, Berenguer Veiga I, Gultom M, Osman S, Zhou B, Adea K, Meyer B, Eberhardt CS, Thomann L, Gsell M, Labroussaa F, Jores J, Summerfield A, Drosten C, Eckerle IA, Wentworth DE, Dijkman R, Hoffmann D, Thiel V, Beer M, Benarafa C. Ulrich L, et al. Among authors: halwe nj. Nature. 2022 Feb;602(7896):307-313. doi: 10.1038/s41586-021-04342-0. Epub 2021 Dec 22. Nature. 2022. PMID: 34937050 Free PMC article.
SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility.
Zhou B, Thao TTN, Hoffmann D, Taddeo A, Ebert N, Labroussaa F, Pohlmann A, King J, Portmann J, Halwe NJ, Ulrich L, Trüeb BS, Kelly JN, Fan X, Hoffmann B, Steiner S, Wang L, Thomann L, Lin X, Stalder H, Pozzi B, de Brot S, Jiang N, Cui D, Hossain J, Wilson M, Keller M, Stark TJ, Barnes JR, Dijkman R, Jores J, Benarafa C, Wentworth DE, Thiel V, Beer M. Zhou B, et al. Among authors: halwe nj. bioRxiv [Preprint]. 2020 Oct 27:2020.10.27.357558. doi: 10.1101/2020.10.27.357558. bioRxiv. 2020. PMID: 33140052 Free PMC article. Updated. Preprint.
Egyptian Fruit Bats (Rousettus aegyptiacus) Were Resistant to Experimental Inoculation with Avian-Origin Influenza A Virus of Subtype H9N2, But Are Susceptible to Experimental Infection with Bat-Borne H9N2 Virus.
Halwe NJ, Gorka M, Hoffmann B, Rissmann M, Breithaupt A, Schwemmle M, Beer M, Kandeil A, Ali MA, Kayali G, Hoffmann D, Balkema-Buschmann A. Halwe NJ, et al. Viruses. 2021 Apr 14;13(4):672. doi: 10.3390/v13040672. Viruses. 2021. PMID: 33919890 Free PMC article.
Experimental SARS-CoV-2 Infection of Bank Voles.
Ulrich L, Michelitsch A, Halwe N, Wernike K, Hoffmann D, Beer M. Ulrich L, et al. Emerg Infect Dis. 2021 Apr;27(4):1193-1195. doi: 10.3201/eid2704.204945. Emerg Infect Dis. 2021. PMID: 33754987 Free PMC article.
Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets.
Halwe NJ, Hamberger L, Sehl-Ewert J, Mache C, Schön J, Ulrich L, Calvelage S, Tönnies M, Fuchs J, Bandawane P, Loganathan M, Abbad A, Carreño JM, Bermúdez-González MC, Simon V, Kandeil A, El-Shesheny R, Ali MA, Kayali G, Budt M, Hippenstiel S, Hocke AC, Krammer F, Wolff T, Schwemmle M, Ciminski K, Hoffmann D, Beer M. Halwe NJ, et al. Nat Commun. 2024 Apr 25;15(1):3450. doi: 10.1038/s41467-024-47455-6. Nat Commun. 2024. PMID: 38664395 Free PMC article.
Omicron subvariant BA.5 efficiently infects lung cells.
Hoffmann M, Wong LR, Arora P, Zhang L, Rocha C, Odle A, Nehlmeier I, Kempf A, Richter A, Halwe NJ, Schön J, Ulrich L, Hoffmann D, Beer M, Drosten C, Perlman S, Pöhlmann S. Hoffmann M, et al. Among authors: halwe nj. Nat Commun. 2023 Jun 13;14(1):3500. doi: 10.1038/s41467-023-39147-4. Nat Commun. 2023. PMID: 37311762 Free PMC article.
12 results