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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, Bretherick AD, Richardson TG, Klughammer J, Iotchkova V, Sharp G, Al Khleifat A, Shatunov A, Iacoangeli A, McArdle WL, Ho KM, Kumar A, Söderhäll C, Soriano-Tárraga C, Giralt-Steinhauer E, Kazmi N, Mason D, McRae AF, Corcoran DL, Sugden K, Kasela S, Cardona A, Day FR, Cugliari G, Viberti C, Guarrera S, Lerro M, Gupta R, Bollepalli S, Mandaviya P, Zeng Y, Clarke TK, Walker RM, Schmoll V, Czamara D, Ruiz-Arenas C, Rezwan FI, Marioni RE, Lin T, Awaloff Y, Germain M, Aïssi D, Zwamborn R, van Eijk K, Dekker A, van Dongen J, Hottenga JJ, Willemsen G, Xu CJ, Barturen G, Català-Moll F, Kerick M, Wang C, Melton P, Elliott HR, Shin J, Bernard M, Yet I, Smart M, Gorrie-Stone T; BIOS Consortium; Shaw C, Al Chalabi A, Ring SM, Pershagen G, Melén E, Jiménez-Conde J, Roquer J, Lawlor DA, Wright J, Martin NG, Montgomery GW, Moffitt TE, Poulton R, Esko T, Milani L, Metspalu A, Perry JRB, Ong KK, Wareham NJ, Matullo G, Sacerdote C, Panico S, Caspi A, Arseneault L, Gagnon F, Ollikainen M, Kaprio J, Felix JF, Rivadeneira F, Tiemeier H, van IJzendoorn MH, Uitterlinden AG, Jaddoe V… See abstract for full author list ➔ Min JL, et al. Among authors: haley c. Nat Genet. 2021 Sep;53(9):1311-1321. doi: 10.1038/s41588-021-00923-x. Epub 2021 Sep 6. Nat Genet. 2021. PMID: 34493871 Free PMC article.
Detecting epistasis in human complex traits.
Wei WH, Hemani G, Haley CS. Wei WH, et al. Nat Rev Genet. 2014 Nov;15(11):722-33. doi: 10.1038/nrg3747. Epub 2014 Sep 9. Nat Rev Genet. 2014. PMID: 25200660 Review.
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.
Zeng Y, Amador C, Xia C, Marioni R, Sproul D, Walker RM, Morris SW, Bretherick A, Canela-Xandri O, Boutin TS, Clark DW, Campbell A, Rawlik K, Hayward C, Nagy R, Tenesa A, Porteous DJ, Wilson JF, Deary IJ, Evans KL, McIntosh AM, Navarro P, Haley CS. Zeng Y, et al. Among authors: haley cs. Nat Commun. 2019 Mar 27;10(1):1383. doi: 10.1038/s41467-019-09301-y. Nat Commun. 2019. PMID: 30918249 Free PMC article.
Bayesian reassessment of the epigenetic architecture of complex traits.
Trejo Banos D, McCartney DL, Patxot M, Anchieri L, Battram T, Christiansen C, Costeira R, Walker RM, Morris SW, Campbell A, Zhang Q, Porteous DJ, McRae AF, Wray NR, Visscher PM, Haley CS, Evans KL, Deary IJ, McIntosh AM, Hemani G, Bell JT, Marioni RE, Robinson MR. Trejo Banos D, et al. Among authors: haley cs. Nat Commun. 2020 Jun 8;11(1):2865. doi: 10.1038/s41467-020-16520-1. Nat Commun. 2020. PMID: 32513961 Free PMC article.
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing.
Zhang Q, Vallerga CL, Walker RM, Lin T, Henders AK, Montgomery GW, He J, Fan D, Fowdar J, Kennedy M, Pitcher T, Pearson J, Halliday G, Kwok JB, Hickie I, Lewis S, Anderson T, Silburn PA, Mellick GD, Harris SE, Redmond P, Murray AD, Porteous DJ, Haley CS, Evans KL, McIntosh AM, Yang J, Gratten J, Marioni RE, Wray NR, Deary IJ, McRae AF, Visscher PM. Zhang Q, et al. Genome Med. 2019 Aug 23;11(1):54. doi: 10.1186/s13073-019-0667-1. Genome Med. 2019. PMID: 31443728 Free PMC article.
493 results