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GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia.
Kim-Muller JY, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, Joaquim S, Stansfield JC, Zhang J, Robertson A, Pang J, Opsahl A, Boucher M, Breen D, Hales K, Sheikh A, Wu Z, Zhang BB. Kim-Muller JY, et al. Among authors: hales k. Cell Rep. 2023 Jan 31;42(1):111947. doi: 10.1016/j.celrep.2022.111947. Epub 2023 Jan 10. Cell Rep. 2023. PMID: 36640326 Free article.
Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
Breen DM, Jagarlapudi S, Patel A, Zou C, Joaquim S, Li X, Kang L, Pang J, Hales K, Ziso-Qejvanaj E, Vera NB, Bennett D, He T, Lambert M, Kelleher K, Wu Z, Zhang BB, Lin L, Seeley RJ, Bezy O. Breen DM, et al. Among authors: hales k. iScience. 2021 May 19;24(6):102554. doi: 10.1016/j.isci.2021.102554. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189431 Free PMC article.
Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension.
Song L, Chen X, Swanson TA, LaViolette B, Pang J, Cunio T, Nagle MW, Asano S, Hales K, Shipstone A, Sobon H, Al-Harthy SD, Ahn Y, Kreuser S, Robertson A, Ritenour C, Voigt F, Boucher M, Sun F, Sessa WC, Roth Flach RJ. Song L, et al. Among authors: hales k. Elife. 2020 Nov 17;9:e58376. doi: 10.7554/eLife.58376. Elife. 2020. PMID: 33200983 Free PMC article.
Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.
Schuler M, Tomlinson L, Homiski M, Cheung J, Zhan Y, Coffing S, Engel M, Rubitski E, Seitis G, Hales K, Robertson A, Vispute S, Cook J, Radi Z, Hollingshead B. Schuler M, et al. Among authors: hales k. Toxicol Sci. 2021 Feb 26;180(1):103-121. doi: 10.1093/toxsci/kfaa189. Toxicol Sci. 2021. PMID: 33481035
α5 nAChR modulation of the prefrontal cortex makes attention resilient.
Howe WM, Brooks JL, Tierney PL, Pang J, Rossi A, Young D, Dlugolenski K, Guillmette E, Roy M, Hales K, Kozak R. Howe WM, et al. Among authors: hales k. Brain Struct Funct. 2018 Mar;223(2):1035-1047. doi: 10.1007/s00429-017-1601-1. Epub 2018 Jan 3. Brain Struct Funct. 2018. PMID: 29299690
De novo lipogenesis is essential for platelet production in humans.
Kelly KL, Reagan WJ, Sonnenberg GE, Clasquin M, Hales K, Asano S, Amor PA, Carvajal-Gonzalez S, Shirai N, Matthews MD, Li KW, Hellerstein MK, Vera NB, Ross TT, Cappon G, Bergman A, Buckeridge C, Sun Z, Qejvanaj EZ, Schmahai T, Beebe D, Pfefferkorn JA, Esler WP. Kelly KL, et al. Among authors: hales k. Nat Metab. 2020 Oct;2(10):1163-1178. doi: 10.1038/s42255-020-00272-9. Epub 2020 Sep 14. Nat Metab. 2020. PMID: 32929234 Clinical Trial.
Structural basis of the acyl-transfer mechanism of human GPAT1.
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H. Johnson ZL, et al. Among authors: hales k. Nat Struct Mol Biol. 2023 Jan;30(1):22-30. doi: 10.1038/s41594-022-00884-7. Epub 2022 Dec 15. Nat Struct Mol Biol. 2023. PMID: 36522428
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
O'Neill BT, Beck EM, Butler CR, Nolan CE, Gonzales C, Zhang L, Doran SD, Lapham K, Buzon LM, Dutra JK, Barreiro G, Hou X, Martinez-Alsina LA, Rogers BN, Villalobos A, Murray JC, Ogilvie K, LaChapelle EA, Chang C, Lanyon LF, Steppan CM, Robshaw A, Hales K, Boucher GG, Pandher K, Houle C, Ambroise CW, Karanian D, Riddell D, Bales KR, Brodney MA. O'Neill BT, et al. Among authors: hales k. J Med Chem. 2018 May 24;61(10):4476-4504. doi: 10.1021/acs.jmedchem.8b00246. Epub 2018 Apr 17. J Med Chem. 2018. PMID: 29613789
172 results