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HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species.
Nat Commun. 2024 Mar 18;15(1):2436. doi: 10.1038/s41467-024-46538-8.
Nat Commun. 2024.
PMID: 38499535
Free PMC article.
APOE genotype regulates pathology and disease progression in synucleinopathy.
Davis AA, Inman CE, Wargel ZM, Dube U, Freeberg BM, Galluppi A, Haines JN, Dhavale DD, Miller R, Choudhury FA, Sullivan PM, Cruchaga C, Perlmutter JS, Ulrich JD, Benitez BA, Kotzbauer PT, Holtzman DM.
Davis AA, et al. Among authors: haines jn.
Sci Transl Med. 2020 Feb 5;12(529):eaay3069. doi: 10.1126/scitranslmed.aay3069.
Sci Transl Med. 2020.
PMID: 32024799
Free PMC article.
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Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration.
Kanan MF, Sheehan PW, Haines JN, Gomez PG, Dhuler A, Nadarajah CJ, Wargel ZM, Freeberg BM, Nelvagal HR, Izumo M, Takahashi JS, Cooper JD, Davis AA, Musiek ES.
Kanan MF, et al. Among authors: haines jn.
JCI Insight. 2024 Jan 23;9(2):e162771. doi: 10.1172/jci.insight.162771.
JCI Insight. 2024.
PMID: 38032732
Free PMC article.
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