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The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. Müller A, et al. Among authors: hailfinger s. J Clin Invest. 2020 Nov 2;130(11):5765-5781. doi: 10.1172/JCI134217. J Clin Invest. 2020. PMID: 32701505 Free PMC article.
IκBζ is a key driver in the development of psoriasis.
Johansen C, Mose M, Ommen P, Bertelsen T, Vinter H, Hailfinger S, Lorscheid S, Schulze-Osthoff K, Iversen L. Johansen C, et al. Among authors: hailfinger s. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5825-33. doi: 10.1073/pnas.1509971112. Epub 2015 Oct 12. Proc Natl Acad Sci U S A. 2015. PMID: 26460049 Free PMC article.
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